ID Q2PZR2_9ACTN Unreviewed; 329 AA.
AC Q2PZR2;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=CosI {ECO:0000313|EMBL:ABC00731.1};
GN Name=cosI {ECO:0000313|EMBL:ABC00731.1};
OS Streptomyces olindensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=358823 {ECO:0000313|EMBL:ABC00731.1};
RN [1] {ECO:0000313|EMBL:ABC00731.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DAUFPE 5622 {ECO:0000313|EMBL:ABC00731.1};
RX PubMed=16810496; DOI=10.1007/s00253-006-0453-z;
RA Garrido L.M., Lombo F., Baig I., Nur-E-Alam M., Furlan R.L., Borda C.C.,
RA Brana A., Mendez C., Salas J.A., Rohr J., Padilla G.;
RT "Insights in the glycosylation steps during biosynthesis of the antitumor
RT anthracycline cosmomycin: characterization of two glycosyltransferase
RT genes.";
RL Appl. Microbiol. Biotechnol. 73:122-131(2006).
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DR EMBL; DQ280500; ABC00731.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2PZR2; -.
DR eggNOG; COG1131; Bacteria.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 8..238
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 329 AA; 35463 MW; 1BC6425D755AAC86 CRC64;
MGGADLAIQT EALKKKYGDK EALAGLDLEV PRGVVYGLLG PNGAGKTTAV RILSTLLKYD
EGTARVAGYD VATQSAQVRY SIGLLGQHAA VDEDLSGRQN LVMFGRLYHI GKRNAQARAD
ELLERFGLTE AAGKPAKQYS GGMRRRLDLA ASLILAPSVL FLDEPTTGLD PRGRNDVWES
VRGLIAEGRT VLLTTQYLEE ADQLADRIAL IDNGRVVESG TPDQLKNKIG GDRIDVVLRR
AHDLERATHT IGTLLRSEPE TDADNRRISV VVDNRVAALT AVARELDDAG IEAEDIALRR
PTLDEVFLNL TGNGAATSAE QSLKEVAQS
//