ID Q2QJI3_9POXV Unreviewed; 1286 AA.
AC Q2QJI3;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=DNA-directed RNA polymerase 147 kDa polypeptide {ECO:0000256|ARBA:ARBA00021673};
DE EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
GN ORFNames=TATV_DAH68_100 {ECO:0000313|EMBL:ABD97666.1};
OS Taterapox virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=28871 {ECO:0000313|EMBL:AAZ17447.1};
RN [1] {ECO:0000313|EMBL:AAZ17447.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Gbl-pox {ECO:0000313|EMBL:AAZ17447.1};
RA Ropp S.L., Meyer H., Frace A.M., Sammons S.A., Govil D., Obsborne J.D.,
RA Bing C., Li Y., Knight J.C., Loparev V.N., Taubenberger J.K., Tsai M.M.,
RA Kolodziejek J., Nowotny N., Esposito J.J.;
RT "Sequence diversity of the orthopoxvirus hemagglutinin gene -- a tool for
RT molecular diagnostics and phylogeny.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABD97666.1, ECO:0000313|Proteomes:UP000139570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dahomey 1968 {ECO:0000313|EMBL:ABD97666.1};
RX PubMed=16873609; DOI=10.1126/science.1125134;
RA Esposito J.J., Sammons S.A., Frace A.M., Osborne J.D., Olsen-Rasmussen M.,
RA Zhang M., Govil D., Damon I.K., Kline R., Laker M., Li Y., Smith G.L.,
RA Meyer H., LeDuc J.W., Wohlhueter R.M.;
RT "Genome sequence diversity and clues to the evolution of variola (smallpox)
RT virus.";
RL Science 313:807-812(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
CC -!- SIMILARITY: Belongs to the poxviridae DNA-directed RNA polymerase 147
CC kDa subunit family. {ECO:0000256|ARBA:ARBA00006884}.
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DR EMBL; DQ066537; AAZ17447.1; -; Genomic_DNA.
DR EMBL; DQ437594; ABD97666.1; -; Genomic_DNA.
DR RefSeq; YP_717407.1; NC_008291.1.
DR GeneID; 4238567; -.
DR KEGG; vg:4238567; -.
DR Proteomes; UP000139570; Genome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000139570};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 188..469
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1286 AA; 146830 MW; 6767961C29B4B9E6 CRC64;
MAVISKVTYS LYDQKDINAT DIIISHVKND DDIGTVKDGR LGAMDGALCK TCGKTELECF
GHWGKVSIYK TNIVKPEFIS EIIRLLNHIC IHCGLLRSRE PYSDDINLKE LSGHALRRLK
DKILSKKKSC WNSECMQPYQ KITFSKKKVC FVNKLDDINV PNSLIYQKLI SIHEKFWPLL
EIHQYPANLF YTDYFPIPPL IIRPAISFWI DSIPKETNEL TYLLGMIVKN CNLNADEQVI
QKAVIEYDDI KIISNNTTSI NLSYITSGKN NMIRSYIVAR RKDQTARSVI GPSTSITVNE
VGMPAYIRNT LTEKIFVNAF TVDKVKQLLA SNQVKFYFNK RLNQLTRIRQ GKFIKNKIHL
LPGDWVEVAV QEYTSIIFGR QPSLHRYNVI ASSIRATEGD TIKISPGIAN SQNADFDGDE
EWMILEQNPK AVVEQSILMY PTTLLKHDIH GAPVYGSIQD EIVAAYSLFR IQDLCLDEVL
NILGKYGREF DPKGKCKFSG KDIYTYLIGE KINYPDLLKD GEIIANDVDS NFVVAMRHLS
LAGLLSDHKS NVEGINFIIK SSYVFKRYLS IYGFGVTFKD LRPNSTFTNK LEAINVEKIE
LIKEAYAKYL KDVRDGKIVP LSKALEADYV ESMLSNLTNL NIREIEEHMR QTLIDDPDNN
LLKMAKAGYK VNPTELMYIL GTYGQQRIDG EPAETRVLGR VLPYYLPDSK DPEGRGYILN
SLTKGLTGSQ YYFSMLVARS QSTDIVCETS RTGTLARKII KKMEDMVVDG YGQVVIGNTL
IKYAANYTKI LGSVCKPVDL IYPDESMTWY LEISALWNKI KQGFVYSQKQ KLAKKTLAPF
NFLVFVKPTT EDNAIKVKDL YDMIHNVIDD VREKYFFTVS NIDFMEYIFL THLNPSRIRI
TKETAITIFE KFYEKLNYTL GGGTPIGIIS AQVLSEKFTQ QALSSFHTTE KSGAVKQKLG
FNEFNNLTNL SKNKTEIITL VSDDISKLQS VKINFEFVCL GELNPDITLR KETDRYVVDI
IVNRLYIKRA EITELVVEYM FERFISFSVI VKEWGMETFI EDEDNIRFTV YLNFVEPEEL
NLSKFMMVLP GAANKGKISK FKIPISDYTG YDDFNQTKKL NKMTVELMNL KELGSFDLEN
VNVYPGVWNT YDIFGIEAAR GYLCEAMLNT YGEGFDYLYQ PCDLLASLLC ASYEPESVNK
FKFGAASTLK RATFGDNKAL LNAALHKKSE PINDNSSCHF FSKVPNIGTG YYKYFIDLGL
LMRMERKLSD KISSQKIKEM EETEDF
//
