GenomeNet

Database: UniProt
Entry: Q2QNC3
LinkDB: Q2QNC3
Original site: Q2QNC3 
ID   MT4C_ORYSJ              Reviewed;          78 AA.
AC   Q2QNC3; B7EXP4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   10-APR-2019, entry version 66.
DE   RecName: Full=Metallothionein-like protein 4C;
DE   AltName: Full=Class I metallothionein-like protein 4C;
DE   AltName: Full=MT-1-4b {ECO:0000303|PubMed:21297036};
DE   AltName: Full=OsMT-I-4c;
DE   AltName: Full=OsMT1c;
GN   Name=MT4C; OrderedLocusNames=Os12g0571100, LOC_Os12g38300;
GN   ORFNames=OsJ_36585 {ECO:0000312|EMBL:EEE53461.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Nipponbare; TISSUE=Root;
RA   Bohnert H.J., Borchert C., Brazille S., Brooks J., Eaton M.,
RA   Ferrea H., Kawasaki S., McCollough A., Michalowski C.B., Palacio C.,
RA   Scara G., Wheeler M., Zepeda G.R.;
RT   "Functional genomics of plant stress tolerance.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease
RT   resistance genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
RA   McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
RA   Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
RA   Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
RA   Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using
RT   next generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H.,
RA   Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J.,
RA   Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X.,
RA   Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y.,
RA   Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J.,
RA   Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y.,
RA   Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y.,
RA   Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z.,
RA   Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T.,
RA   Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H.,
RA   Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA   Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA   Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J.,
RA   Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [8]
RP   GENE FAMILY, AND TISSUE SPECIFICITY.
RX   PubMed=17002881; DOI=10.5483/BMBRep.2006.39.5.595;
RA   Zhou G., Xu Y., Li J., Yang L., Liu J.-Y.;
RT   "Molecular analyses of the metallothionein gene family in rice (Oryza
RT   sativa L.).";
RL   J. Biochem. Mol. Biol. 39:595-606(2006).
RN   [9]
RP   FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=21297036; DOI=10.1105/tpc.110.074369;
RA   Hu L., Liang W., Yin C., Cui X., Zong J., Wang X., Hu J., Zhang D.;
RT   "Rice MADS3 regulates ROS homeostasis during late anther
RT   development.";
RL   Plant Cell 23:515-533(2011).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine
CC       residues that bind various heavy metals (Probable). Acts as
CC       reactive oxygen species (ROS) scavenger. Possesses superoxide
CC       anion and hydroxyl radical scavenging activities in vitro.
CC       Involved in ROS homeostasis during anther and pollen development
CC       (PubMed:21297036). {ECO:0000269|PubMed:21297036, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in roots (PubMed:21297036).
CC       Expressed in leaves, rachis, inflorescences and seeds
CC       (PubMed:17002881). {ECO:0000269|PubMed:17002881,
CC       ECO:0000269|PubMed:21297036}.
CC   -!- DEVELOPMENTAL STAGE: During anther development, expressed from
CC       stage 8 to stage 12. {ECO:0000269|PubMed:21297036}.
CC   -!- MISCELLANEOUS: Plants silencing MT4C show decreased pollen
CC       fertility and increased level of superoxide anion.
CC       {ECO:0000269|PubMed:21297036}.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 15
CC       family. {ECO:0000305}.
DR   EMBL; BE039221; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; DP000011; ABA99661.1; -; Genomic_DNA.
DR   EMBL; AP008218; BAF30102.1; -; Genomic_DNA.
DR   EMBL; AP014968; BAT17739.1; -; Genomic_DNA.
DR   EMBL; CM000149; EEE53461.1; -; Genomic_DNA.
DR   EMBL; AK105219; BAG97141.1; -; mRNA.
DR   RefSeq; XP_015620236.1; XM_015764750.1.
DR   UniGene; Os.37783; -.
DR   UniGene; Os.57928; -.
DR   STRING; 4530.OS12T0571100-01; -.
DR   PRIDE; Q2QNC3; -.
DR   EnsemblPlants; Os12t0571100-01; Os12t0571100-01; Os12g0571100.
DR   GeneID; 4352582; -.
DR   Gramene; Os12t0571100-01; Os12t0571100-01; Os12g0571100.
DR   KEGG; osa:4352582; -.
DR   HOGENOM; HOG000220916; -.
DR   InParanoid; Q2QNC3; -.
DR   OMA; GCKRYPD; -.
DR   OrthoDB; 1627904at2759; -.
DR   Proteomes; UP000059680; Chromosome 12.
DR   Genevisible; Q2QNC3; OS.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009555; P:pollen development; IMP:UniProtKB.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
DR   InterPro; IPR000347; Metalthion_15p.
DR   PANTHER; PTHR33543; PTHR33543; 1.
DR   Pfam; PF01439; Metallothio_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Metal-binding; Metal-thiolate cluster;
KW   Reference proteome; Stress response.
FT   CHAIN         1     78       Metallothionein-like protein 4C.
FT                                /FTId=PRO_0000263061.
SQ   SEQUENCE   78 AA;  7514 MW;  0AF2B6CBEBC51E13 CRC64;
     MSCGGSCNCG SCGCGGGCGK MYPDLAEKIT TTTTTATTVL GVAPEKGHSE GVGKAAESGE
     AAHGCSCGSS CRCNPCNC
//
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