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Database: UniProt
Entry: Q2R114
LinkDB: Q2R114
Original site: Q2R114 
ID   CADH4_ORYSJ             Reviewed;         354 AA.
AC   Q2R114; A0A0P0Y4L1; Q0IRJ9;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 2.
DT   13-FEB-2019, entry version 94.
DE   RecName: Full=Putative cinnamyl alcohol dehydrogenase 4 {ECO:0000305};
DE            Short=OsCAD4 {ECO:0000303|PubMed:15452707};
DE            EC=1.1.1.195;
GN   Name=CAD4 {ECO:0000303|PubMed:15452707};
GN   OrderedLocusNames=Os11g0622800, LOC_Os11g40690;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease
RT   resistance genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
RA   McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
RA   Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
RA   Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
RA   Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using
RT   next generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15452707; DOI=10.1007/s00425-004-1385-4;
RA   Tobias C.M., Chow E.K.;
RT   "Structure of the cinnamyl-alcohol dehydrogenase gene family in rice
RT   and promoter activity of a member associated with lignification.";
RL   Planta 220:678-688(2005).
CC   -!- FUNCTION: Involved in lignin biosynthesis. Catalyzes the final
CC       step specific for the production of lignin monomers. Catalyzes the
CC       NADPH-dependent reduction of coniferaldehyde, 5-
CC       hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and
CC       caffeyl aldehyde to their respective alcohols.
CC       {ECO:0000250|UniProtKB:O49482}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde +
CC         H(+) + NADPH; Xref=Rhea:RHEA:10392, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16731, ChEBI:CHEBI:33227, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.1.1.195;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000250|UniProtKB:O49482};
CC       Note=Binds 2 Zn(2+) ions per subunit.
CC       {ECO:0000250|UniProtKB:O49482};
CC   -!- PATHWAY: Aromatic compound metabolism; phenylpropanoid
CC       biosynthesis.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:O49482}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABA94833.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAF28666.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AC104845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DP000010; ABA94833.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008217; BAF28666.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014967; BAT14915.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q2R114; -.
DR   SMR; Q2R114; -.
DR   STRING; 39947.LOC_Os11g40690.1; -.
DR   PaxDb; Q2R114; -.
DR   EnsemblPlants; Os11t0622800-00; Os11t0622800-00; Os11g0622800.
DR   Gramene; Os11t0622800-00; Os11t0622800-00; Os11g0622800.
DR   eggNOG; KOG0023; Eukaryota.
DR   eggNOG; COG1064; LUCA.
DR   InParanoid; Q2R114; -.
DR   OMA; AGRENMC; -.
DR   UniPathway; UPA00711; -.
DR   Proteomes; UP000059680; Chromosome 11.
DR   GO; GO:0045551; F:cinnamyl-alcohol dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052747; F:sinapyl alcohol dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009809; P:lignin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Lignin biosynthesis; Metal-binding; NADP;
KW   Oxidoreductase; Reference proteome; Zinc.
FT   CHAIN         1    354       Putative cinnamyl alcohol dehydrogenase
FT                                4.
FT                                /FTId=PRO_0000382643.
FT   NP_BIND     188    193       NADP. {ECO:0000250|UniProtKB:O49482}.
FT   NP_BIND     211    216       NADP. {ECO:0000250|UniProtKB:O49482}.
FT   NP_BIND     297    299       NADP. {ECO:0000250|UniProtKB:O49482}.
FT   METAL        47     47       Zinc 1; catalytic.
FT                                {ECO:0000250|UniProtKB:O49482}.
FT   METAL        69     69       Zinc 1; catalytic.
FT                                {ECO:0000250|UniProtKB:O49482}.
FT   METAL        70     70       Zinc 1; catalytic.
FT                                {ECO:0000250|UniProtKB:O49482}.
FT   METAL       100    100       Zinc 2. {ECO:0000250|UniProtKB:O49482}.
FT   METAL       103    103       Zinc 2. {ECO:0000250|UniProtKB:O49482}.
FT   METAL       106    106       Zinc 2. {ECO:0000250|UniProtKB:O49482}.
FT   METAL       114    114       Zinc 2. {ECO:0000250|UniProtKB:O49482}.
FT   METAL       163    163       Zinc 1; catalytic.
FT                                {ECO:0000250|UniProtKB:O49482}.
FT   BINDING     167    167       NADP. {ECO:0000250|UniProtKB:O49482}.
FT   BINDING     251    251       NADP. {ECO:0000250|UniProtKB:O49482}.
SQ   SEQUENCE   354 AA;  38635 MW;  87895E62FE3D8F0F CRC64;
     MAAECGSGNC DAWAARDPSG ILSPYKFNRR EVQSEDVSLR ITHCGVCYAD VIWTRNMFND
     SIYPLVPGHE IAGVVTEVGA DVKGFKVGDH VGVGVYVNSC QDCENCNSSL ENHCSKCVVT
     YNSVDSDGTV TKGGYSSHIL VHQRYCFKIP ADYPLSKAAP LLCAGITVYT PMIRHNMNQP
     GKSLGVIGLG GLGHMAVKFG KAFGLKVTVF STSESKREEA INLLGADNFV ISSDENQMES
     LKSSLHFIID TASGDHQFDP YLSLLKVGGV MVLLSFPSEI KVHPENLNLA ARSLAGSVTG
     GTKDIQEMIN FCAANNVYPD IEMIKIDYVN EALQRLINRD VRFRFVIDIE NSFK
//
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