ID Q2RK91_MOOTA Unreviewed; 444 AA.
AC Q2RK91;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Radical SAM {ECO:0000313|EMBL:ABC19148.1};
GN OrderedLocusNames=Moth_0831 {ECO:0000313|EMBL:ABC19148.1};
OS Moorella thermoacetica (strain ATCC 39073 / JCM 9320).
OC Bacteria; Bacillota; Clostridia; Moorellales; Moorellaceae; Moorella.
OX NCBI_TaxID=264732 {ECO:0000313|EMBL:ABC19148.1};
RN [1] {ECO:0000313|EMBL:ABC19148.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 39073 {ECO:0000313|EMBL:ABC19148.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chertkov O., Saunders E.H., Brettin T.,
RA Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Anderson I., Richardson P., Ragsdale S.;
RT "Complete sequence of Moorella thermoacetica ATCC 39073.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000232; ABC19148.1; -; Genomic_DNA.
DR RefSeq; YP_429691.1; NC_007644.1.
DR AlphaFoldDB; Q2RK91; -.
DR STRING; 264732.Moth_0831; -.
DR EnsemblBacteria; ABC19148; ABC19148; Moth_0831.
DR KEGG; mta:Moth_0831; -.
DR PATRIC; fig|264732.11.peg.893; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_5_1_9; -.
DR OrthoDB; 9801424at2; -.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR020612; Methylthiotransferase_CS.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF12; BLL1977 PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS01278; MTTASE_RADICAL; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 46..131
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 155..371
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 444 AA; 50184 MW; DD862403C8104FBB CRC64;
MKIALIAPAW HDPLWESEKE KSIFPPLNLI TLAAMTPPQH EVTILDESLT DLDFNEKYDL
VGISAMTALA PRAYEIADAF RERGTMVVLG GMHPSALPEE AIAHADAVVV GEAEGSWQRL
LTDLENGQLQ AFYRQEKRPS LEHMVIPRRD LLQRSRYLVP DTVQTTRGCP FACSFCSVSQ
FFGHSYRFRP VEEVISEVRD LEGEVIAFID DNIVGNPAYA RRLFTELARL PRKVKWFSQG
SLNIARDEEL LRLAAASGCI GLFIGFESLS PANLKAVGKR VNLVDDYRQA IKKLHDHGIA
IEGAFVFGLD EDDESVFERT VKFAQENRLE AAQFGILTPF PGTPLREALE REGRITNNDW
SEYTISKVVF EPKNMSARTL QEGFNWAWQE FYSLGSISRR LGLAKKHAAI LWALNLNIRK
RFNHFMERLR AGNLGLPQPS LARQ
//
