ID Q2RRF7_RHORT Unreviewed; 604 AA.
AC Q2RRF7;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Rru_A2488 {ECO:0000313|EMBL:ABC23288.1};
OS Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 /
OS NCIMB 8255 / S1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Rhodospirillum.
OX NCBI_TaxID=269796 {ECO:0000313|EMBL:ABC23288.1, ECO:0000313|Proteomes:UP000001929};
RN [1] {ECO:0000313|EMBL:ABC23288.1, ECO:0000313|Proteomes:UP000001929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1
RC {ECO:0000313|Proteomes:UP000001929};
RX PubMed=21886856; DOI=10.4056/sigs.1804360;
RA Munk A.C., Copeland A., Lucas S., Lapidus A., Del Rio T.G., Barry K.,
RA Detter J.C., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Kyrpides N.C.,
RA Mavromatis K., Richardson P., Rohde M., Goker M., Klenk H.P., Zhang Y.,
RA Roberts G.P., Reslewic S., Schwartz D.C.;
RT "Complete genome sequence of Rhodospirillum rubrum type strain (S1).";
RL Stand. Genomic Sci. 4:293-302(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP000230; ABC23288.1; -; Genomic_DNA.
DR RefSeq; WP_011390241.1; NC_007643.1.
DR RefSeq; YP_427575.1; NC_007643.1.
DR AlphaFoldDB; Q2RRF7; -.
DR STRING; 269796.Rru_A2488; -.
DR REBASE; 11702; M.RruMORF2488P.
DR EnsemblBacteria; ABC23288; ABC23288; Rru_A2488.
DR KEGG; rru:Rru_A2488; -.
DR PATRIC; fig|269796.9.peg.2592; -.
DR eggNOG; COG0827; Bacteria.
DR HOGENOM; CLU_032205_0_0_5; -.
DR Proteomes; UP000001929; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ABC23288.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001929};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 128..296
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 63383 MW; 69249CDF7C0CE8E6 CRC64;
MTPCGTASTS PEKSAAILAG PPSPGVEGTR SDLARARVVA RAWAETLTPA RRADQALLFT
TAAMAALRKG IGVEAVARPG FARPRGRLDH AGARVAQAIG EDAALLPLAE ALHLITGLYP
ALLPARERGA LGAFYTPIAL VERLLDRATE EGADWAGLRL LDPAAGGGAF LLGAVARIRA
ALAGCEPAFI LGRIGARVLG LEVDARAAAL AQAALDILLA DLAQAAGRPP PVVLRVADTL
EIPADPSFDL VVGNPPYGRV GLTPAQRARF GRGLYGHANL YGVFTDIALR WTAPGGLIAY
LTPTSFLAGR YYGALRGLLA AEAPPLSIDF VHARQGVFED VLQETLLALY RRGGQAGRVR
IHYLTLDGEG RARIAHNGTI GLPADAGAPW LAPRDPGQGH LVARVEAMGH RLAEWGYGVS
TGPLVWNRYK GQLRDRPTGK RVHPLIWAEA VTADGRFVFR AAKRNHAPYF KLQAGDDALL
VGEPCVLVQR TTAKEQHRRL IAAELPAAFV AGHGGVVVEN HLNMVRAKGT PRVAPAVVAA
LLNSAVVDQV FRCMSGSVAV SAFELEALPL PAAGDLGPLT ALVAAGAPRD DIEAECARLY
GKGL
//
