ID Q2S0F5_SALRD Unreviewed; 437 AA.
AC Q2S0F5;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=argininosuccinate lyase {ECO:0000256|ARBA:ARBA00012338};
DE EC=4.3.2.1 {ECO:0000256|ARBA:ARBA00012338};
GN Name=argH {ECO:0000313|EMBL:ABC44970.1};
GN OrderedLocusNames=SRU_2221 {ECO:0000313|EMBL:ABC44970.1};
OS Salinibacter ruber (strain DSM 13855 / M31).
OC Bacteria; Rhodothermota; Rhodothermia; Rhodothermales; Salinibacteraceae;
OC Salinibacter.
OX NCBI_TaxID=309807 {ECO:0000313|EMBL:ABC44970.1, ECO:0000313|Proteomes:UP000008674};
RN [1] {ECO:0000313|EMBL:ABC44970.1, ECO:0000313|Proteomes:UP000008674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13855 / CECT 5946 / M31
RC {ECO:0000313|Proteomes:UP000008674};
RX PubMed=16330755; DOI=10.1073/pnas.0509073102;
RA Mongodin E.F., Nelson K.E., Daugherty S., Deboy R.T., Wister J., Khouri H.,
RA Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K.,
RA Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L.,
RA Legault B., Rodriguez-Valera F.;
RT "The genome of Salinibacter ruber: convergence and gene exchange among
RT hyperhalophilic bacteria and archaea.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000985};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3.
CC {ECO:0000256|ARBA:ARBA00004941}.
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DR EMBL; CP000159; ABC44970.1; -; Genomic_DNA.
DR RefSeq; WP_011404947.1; NC_007677.1.
DR RefSeq; YP_446326.1; NC_007677.1.
DR AlphaFoldDB; Q2S0F5; -.
DR STRING; 309807.SRU_2221; -.
DR EnsemblBacteria; ABC44970; ABC44970; SRU_2221.
DR KEGG; sru:SRU_2221; -.
DR PATRIC; fig|309807.25.peg.2314; -.
DR eggNOG; COG0165; Bacteria.
DR HOGENOM; CLU_027272_2_0_10; -.
DR OrthoDB; 9769623at2; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000008674; Chromosome.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00838; argH; 1.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW Lyase {ECO:0000313|EMBL:ABC44970.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008674}.
FT DOMAIN 36..299
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT REGION 391..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 47374 MW; AA1C2A02E13FA590 CRC64;
MTAPLWQKDA TPATDDWAHR FTVGDDYEWD RLLLPYDVRA SRAHAWGLRQ IDVLSETEWT
RIGDALDALL DAFEAGDVTV TPEDEDCHTV IERFVTERAG AAGEKLHTGR SRNDQVLAAL
RLYLRDALAA IGGRAAALAD ALCELATRHP DVLMPGYTHL QRAMPSTAAL WTLGYAETLA
GDLDALRHAR RRINVSPLGS AAGYGVPVID LPREAVADRL GFRAVQTHAT AVQLSRGKHA
LAVGHACTQV GATCNRLASD LVLFATAEFD FVDLPPEHCT GSSIMPQKQN PDVLELARAY
HHRLAAQMQS LATGPSNLPG GYHRDLQLTK AAVLRSVEMT SDVLTALAEV VRGVTFNPER
TRAACAPDIL ATQRALERVA EGVPFRSAYQ QAADAEPGPV DPGAVLDAYE TDGTPGQERP
DRVRSRLDAH GDWVVTP
//
