GenomeNet

Database: UniProt
Entry: Q2TA51
LinkDB: Q2TA51
Original site: Q2TA51 
ID   KRA55_MOUSE             Reviewed;         241 AA.
AC   Q2TA51;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   10-APR-2019, entry version 83.
DE   RecName: Full=Keratin-associated protein 5-5;
GN   Name=Krtap5-5 {ECO:0000312|MGI:MGI:2149673};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:AAI11114.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
CC       are embedded in an interfilamentous matrix, consisting of hair
CC       keratin-associated protein (KRTAP), which are essential for the
CC       formation of a rigid and resistant hair shaft through their
CC       extensive disulfide bond cross-linking with abundant cysteine
CC       residues of hair keratins. The matrix proteins include the high-
CC       sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 5 family.
CC       {ECO:0000250|UniProtKB:Q701N2}.
DR   EMBL; BC111113; AAI11114.1; -; mRNA.
DR   CCDS; CCDS22026.1; -.
DR   RefSeq; NP_001032911.1; NM_001037822.1.
DR   UniGene; Mm.444495; -.
DR   ProteinModelPortal; Q2TA51; -.
DR   STRING; 10090.ENSMUSP00000095555; -.
DR   PaxDb; Q2TA51; -.
DR   PRIDE; Q2TA51; -.
DR   Ensembl; ENSMUST00000097942; ENSMUSP00000095555; ENSMUSG00000073785.
DR   GeneID; 114666; -.
DR   KEGG; mmu:114666; -.
DR   UCSC; uc009kmq.1; mouse.
DR   CTD; 439915; -.
DR   MGI; MGI:2149673; Krtap5-5.
DR   GeneTree; ENSGT00940000164129; -.
DR   OMA; CCWPSGL; -.
DR   PRO; PR:Q2TA51; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000073785; Expressed in 13 organ(s), highest expression level in skin of back.
DR   Genevisible; Q2TA51; MM.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 3.
PE   2: Evidence at transcript level;
KW   Complete proteome; Keratin; Reference proteome; Repeat.
FT   CHAIN         1    241       Keratin-associated protein 5-5.
FT                                /FTId=PRO_0000361661.
FT   REPEAT       35     38       1. {ECO:0000255}.
FT   REPEAT       41     44       2. {ECO:0000255}.
FT   REPEAT       47     50       3. {ECO:0000255}.
FT   REPEAT      105    108       4. {ECO:0000255}.
FT   REPEAT      115    118       5. {ECO:0000255}.
FT   REPEAT      133    136       6. {ECO:0000255}.
FT   REPEAT      143    146       7. {ECO:0000255}.
FT   REPEAT      161    164       8. {ECO:0000255}.
FT   REPEAT      171    174       9. {ECO:0000255}.
FT   REPEAT      181    184       10. {ECO:0000255}.
FT   REPEAT      191    194       11. {ECO:0000255}.
FT   REPEAT      201    204       12. {ECO:0000255}.
FT   REPEAT      211    214       13. {ECO:0000255}.
FT   REPEAT      221    224       14. {ECO:0000255}.
FT   REPEAT      231    234       15. {ECO:0000255}.
FT   REGION       35    234       15 X 4 AA repeats of C-C-X-P.
FT                                {ECO:0000255}.
FT   COMPBIAS      3    239       Cys-rich. {ECO:0000255}.
SQ   SEQUENCE   241 AA;  23063 MW;  41A73039A2C9E91E CRC64;
     MTCCGCSGGC GSSCGGCGCS GGCGSSCGGC GSSCCCKPVC CCKPVCCCVP ACSCSSCGGC
     KGGCGSCGGC KGSCGSCGGC KGGCGSCGGC GSCGGCKPSC CQSSCCKPCC CQSSCCKPCC
     SSGCGSSCCQ SSCCKPCCCQ SSCCKPCCSS GCGSSCCQSS CCKPCCCQSS CCKPCCCQSS
     CCKPCCCQSS CCKPCCCQSS CCKPCCCQSS CCKPCCCQSS CCKPCCCQSS CCAPVCCQCK
     I
//
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