ID Q2THG5_MOUSE Unreviewed; 154 AA.
AC Q2THG5;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE RecName: Full=Interleukin family protein {ECO:0000256|RuleBase:RU368043};
GN Name=Il20 {ECO:0000313|Ensembl:ENSMUSP00000141088.2,
GN ECO:0000313|MGI:MGI:1890473};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAW78349.1};
RN [1] {ECO:0000313|EMBL:AAW78349.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/c {ECO:0000313|EMBL:AAW78349.1};
RA Chang M.-S.;
RT "IL-20: promoter analysis and characterization of biological function.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000141088.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141088.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000141088.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141088.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Immune regulatory cytokine. {ECO:0000256|RuleBase:RU368043}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU368043}.
CC -!- SIMILARITY: Belongs to the IL-10 family.
CC {ECO:0000256|ARBA:ARBA00008813, ECO:0000256|RuleBase:RU368043}.
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DR EMBL; AY876923; AAW78349.1; -; mRNA.
DR RefSeq; NP_001298020.1; NM_001311091.1.
DR Antibodypedia; 34589; 581 antibodies from 31 providers.
DR DNASU; 58181; -.
DR Ensembl; ENSMUST00000188581.2; ENSMUSP00000141088.2; ENSMUSG00000026416.13.
DR GeneID; 58181; -.
DR UCSC; uc011wrm.1; mouse.
DR AGR; MGI:1890473; -.
DR CTD; 50604; -.
DR MGI; MGI:1890473; Il20.
DR VEuPathDB; HostDB:ENSMUSG00000026416; -.
DR GeneTree; ENSGT00950000183124; -.
DR OrthoDB; 5347451at2759; -.
DR BioGRID-ORCS; 58181; 1 hit in 77 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000026416; Expressed in animal zygote and 15 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020442; IL-20.
DR PANTHER; PTHR48394; INTERLEUKIN-19-RELATED; 1.
DR PANTHER; PTHR48394:SF4; INTERLEUKIN-20; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01935; INTRLEUKIN20.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 2: Evidence at transcript level;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU368043};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR620443-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368043};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DISULFID 33..104
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
FT DISULFID 58..110
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
FT DISULFID 59..112
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
SQ SEQUENCE 154 AA; 17543 MW; 067AE057DDF3DE28 CRC64;
MKGFGLAFGL FSAVGFLLWT PLTGLKTLHL GSCVITANLQ AIQKEFSEIR DSVSLDRCCF
LRHLVRFYLD RVFKVYQTPD HHTLRKISSL ANSFLIIKKD LSVCHSHMAC HCGEEAMEKY
NQILSHFIEL ELQAAVVKAL GELGILLRWM EEML
//
