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Database: UniProt
Entry: Q2TZH4
LinkDB: Q2TZH4
Original site: Q2TZH4 
ID   SET9_ASPOR              Reviewed;         625 AA.
AC   Q2TZH4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   16-JAN-2019, entry version 74.
DE   RecName: Full=Histone-lysine N-methyltransferase set9;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain protein 9;
GN   Name=set9; ORFNames=AO090011000851;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G.,
RA   Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K.,
RA   Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W.,
RA   Galagan J.E., Nierman W.C., Yu J., Archer D.B., Bennett J.W.,
RA   Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H.,
RA   Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R.,
RA   Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N.,
RA   Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I.,
RA   Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y.,
RA   Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y.,
RA   Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K.,
RA   Kuhara S., Ogasawara N., Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Histone methyltransferase that specifically methylates
CC       'Lys-20' of histone H4. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00900};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00900}.
DR   EMBL; AP007171; BAE65291.1; -; Genomic_DNA.
DR   RefSeq; XP_001826424.2; XM_001826372.2.
DR   ProteinModelPortal; Q2TZH4; -.
DR   SMR; Q2TZH4; -.
DR   PRIDE; Q2TZH4; -.
DR   EnsemblFungi; BAE65291; BAE65291; AO090011000851.
DR   GeneID; 5998527; -.
DR   KEGG; aor:AO090011000851; -.
DR   HOGENOM; HOG000214006; -.
DR   KO; K11429; -.
DR   OMA; IYLPDCP; -.
DR   Proteomes; UP000006564; Chromosome 7.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:InterPro.
DR   InterPro; IPR025783; Hist-Lys_N-MeTrfase_SET9.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    625       Histone-lysine N-methyltransferase set9.
FT                                /FTId=PRO_0000281799.
FT   DOMAIN      120    234       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   625 AA;  70383 MW;  ED6A776AF259BB94 CRC64;
     MPSSKARDSP SVERRDRLTL AKLASYDDVA TDALVDRAYF WTNTRKNRTK YIPVRGVHED
     DVARILLHEV IVAKDSAQAE KQLLAMSGMK KYLAKLPNDR EKEWFRRHLR KYIQMYLPDS
     PFEVTTTNRY TITEHEAAIC ARKFIKQGQE IKYLSGTLVP MTREEEQELD LKRKDFSIVM
     SSRRKTPSFF LGPARFANHD CNANGRLVTR GSEGMQVVAT RDIYIGEEIT VSYGDDYFGI
     DNCECLCLTC ERAVRNGWAP HVDSEEGSSK ASTPALNDEA ISNDSLLSPR KRKHHLDSDS
     DISPSSTPRK RSKFTRQSSK LRSAVSLADF APVGSGSDNP PPQAETSIVP ETTGAASITN
     DTIVPASGSA VEVSQASATD CDSSPSLEAD ESHHSSTSTT PTSIGDVKIK VEDTVEASLT
     ESASATHITL SITGQPHNDR HPPGTDNDML SELSEITDNP QKPKRSRGSR WKHGVVPSVE
     EESHRVRVPG DYTKTSKLLA QAYDRWVDCH TCNVWFVQHN SYLTRRECPR CERHSMLYGF
     RWPKTDKEGS MDDEERVMDH RTVHRFLYPE EEARISRKDR GVSFGVTPTP ELSEPRTETE
     DSEACDDRRN TRASRTRTRS LRMTM
//
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