ID ATFB_ASPOR Reviewed; 318 AA.
AC Q2U616;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 22-FEB-2023, entry version 58.
DE RecName: Full=Basic leucine zipper (bZIP) transcription factor atfB {ECO:0000303|PubMed:18448366};
GN Name=atfB {ECO:0000303|PubMed:18448366}; ORFNames=AO090120000418;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
RN [2]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=18448366; DOI=10.1016/j.fgb.2008.03.009;
RA Sakamoto K., Arima T.H., Iwashita K., Yamada O., Gomi K., Akita O.;
RT "Aspergillus oryzae atfB encodes a transcription factor required for stress
RT tolerance in conidia.";
RL Fungal Genet. Biol. 45:922-932(2008).
CC -!- FUNCTION: Transcription factor that acts as a key player in the
CC regulatory circuit that integrates secondary metabolism and cellular
CC response to oxidative stress (By similarity). Regulates the genes
CC involved in development and stress response through direct binding to
CC their promoters (PubMed:18448366). Particularly involved in the
CC resistance to oxidative stress in asexual conidiospores
CC (PubMed:18448366). {ECO:0000250|UniProtKB:A0A0F0IP79,
CC ECO:0000269|PubMed:18448366}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- INDUCTION: Expression is barely detectable at the basal hyphal growth
CC phase but induced during conidial development (PubMed:18448366).
CC {ECO:0000269|PubMed:18448366}.
CC -!- DISRUPTION PHENOTYPE: Leads to weak conidia formation on hyperosmotic
CC medium (PubMed:18448366). {ECO:0000269|PubMed:18448366}.
CC -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000305}.
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DR EMBL; AP007166; BAE62999.1; -; Genomic_DNA.
DR RefSeq; XP_001824132.1; XM_001824080.2.
DR AlphaFoldDB; Q2U616; -.
DR SMR; Q2U616; -.
DR STRING; 510516.Q2U616; -.
DR EnsemblFungi; BAE62999; BAE62999; AO090120000418.
DR GeneID; 5996391; -.
DR KEGG; aor:AO090120000418; -.
DR VEuPathDB; FungiDB:AO090120000418; -.
DR HOGENOM; CLU_888511_0_0_1; -.
DR OMA; HAQCGDE; -.
DR OrthoDB; 1409438at2759; -.
DR Proteomes; UP000006564; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0034605; P:cellular response to heat; IMP:AspGD.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IMP:AspGD.
DR CDD; cd14687; bZIP_ATF2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR19304:SF5; ACTIVATING TRANSCRIPTION FACTOR-2; 1.
DR PANTHER; PTHR19304; CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..318
FT /note="Basic leucine zipper (bZIP) transcription factor
FT atfB"
FT /id="PRO_0000444004"
FT DOMAIN 160..223
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 114..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..199
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 202..216
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 275..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 35944 MW; 5BD70DDA8AADAADA CRC64;
MSVDQTLYSR TPTAMADPTC AGPAAFTAAG AFSQPDLMAF SLREEEPIWG FDTIAPSMAS
WQGKMEQQTF CNPNMERGLK NTHVRNGQPT PPPFDDKKLQ TPMGEMYPVA QYAFNSSPPE
YAPPKHRSSL SEQSQTDGYG VSTRRRKASA IDQCEQQQER EKREKFLERN RLAASKCRQK
KKEHTKLLET RFREVSNKKG ELESEIEHLR SEVLNLKNEM LRHAQCGDEA IKIHLAQMVR
LITSKDTPNR DLVSPMRSPE QMAASTPHGL SFGFDGPMQL PSEMGSPLDQ RRDSEQSIMT
ESSYTFSTDD SFEELINV
//
