ID Q2U6I5_ASPOR Unreviewed; 1774 AA.
AC Q2U6I5;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Ras GTPase activating protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AO090120000221 {ECO:0000313|EMBL:BAE62830.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE62830.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE62830.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
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DR EMBL; AP007166; BAE62830.1; -; Genomic_DNA.
DR STRING; 510516.Q2U6I5; -.
DR EnsemblFungi; BAE62830; BAE62830; AO090120000221.
DR VEuPathDB; FungiDB:AO090120000221; -.
DR HOGENOM; CLU_000972_1_1_1; -.
DR OMA; KGVLVHW; -.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000006564; Chromosome 5.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd21206; CH_IQGAP; 1.
DR CDD; cd05127; RasGAP_IQGAP_like; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 11.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 10.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006564}.
FT DOMAIN 296..407
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1138..1354
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1774 AA; 203387 MW; 1F9C6ACDF71D6109 CRC64;
MSSHSAPIRR TQTDFPTQTS SPLRHGSTAS TNSSIYSIST DSLAPSRTST VSSTGSMGST
PSFGHKRGKS EVNTMSADRF KADSRWSNAG TTYENVRRSL RPLSQAPNAS PSAVKQVAYG
HSRSRTIYNP QFWKENRPQT PERRNGYHGE IEPLKEIESH DVYAPPSPKS PQDFSPLAVS
PQTRSPSKTQ HSHSLSTPQP PPLTTTLSTP ELETFQKSST GHLRTLSKFA QSGETEEFAL
DSPSVVGLVG RRRLKRTDSV AGSGSANINR RKNASSWAAG NWMDKQRQFL QAYEYLCHIG
EAKEWIEEVI HKQIPPIVQL EEALRDGVTL AEVVQAMYPN RMLRIFRHPK LQYRHSDNIA
LFFRFLDEVE LPELFRFELI DLYEKKNIPK VIHCVHALSW LLFKKGLVDF RMGNLVGQLE
FEHHELEKTQ KGLDKAGVSM PSFSGMAANF GADPEPEPEP EPESEEDRIE RELHENEASI
ADFQAQVKGA MLRLKLGNLM NNLWDFEPFL IDLQSRIRGD WARQIVQYCL DMRAFAINLQ
AICRGFIVRC RQNDDMESYQ AQEPGILELQ TLIRASKARA QVQYLQSQMR KEESGIKEIQ
AAIRGALQRK SVSALYYDTR DAEDHVRLLQ AAIRGALQRK TVGALYDDIR DAEDQVRLLQ
SIIRGGLLRN KLSKQCEETK SAEDAIRDLQ SLIRGFFTRR QMNAQYADMD SVQGNVELLQ
AAIRGSLARN SLSQMRDLLD QQAPSIIAIQ SGARALAVRK QQTILAEALG KAEDRFITLQ
AMARGNAARE RLDCLRKDLM EHVELLISLQ SILRGRATRS FLASQQKALR DEEASILELQ
SMARGSLVRR RLEADAEALQ AEELTIIDLQ ALARAAVLRI EVGGILEQLD DCDDEVSQLQ
AHIRAMLVRV EVGQSLADLA AEEDVITDLQ SHIRGHIIRS KFEEKRRYYR ENMEKVIKAQ
SFVRGRIQGQ AYKSLTSGKN PPVGTVKGFV HLLNDSEFDF DEEIEFERMR KLVVQQVRQN
ELAEQYISQL DIKIALLVKN KITLDEVVKH QKHFGGHVGS LLPNREIASK DPFDLKALNK
TSRRKLEQYQ VLFFLLQTQS QYLAKLFRRL RELNTSEKEY ERTRHLMMGL FGYSQKRREE
YYLIKLLARS AREEIESFDS LHDYLRCNSF WTKLFASYIK SPRDRKFMRD VLGTVVKENI
IDNPELDLES DPIQIYRSAI NNEELRTGKR SRRPLDIPRE DAIRDPETRA TFIQHLQDLR
DIADQFFTAF EELLYRMPFG LRYIAKEMYE SLLSRFAGDD PGFILQTTGH WVWKNYFQPA
LIEPEKHGVV DRGLTQEQKR NLSEIAKVIA QVASGRLFGT ENVYLQPLNS YIGDSIQRLG
HIWGDMISVQ DAEAYFDIDE FNDLYAKTKP TLYIKLSDIF SIHQLVASEI HYICPNPDDI
LKEVIRDLGN VKSNENELMS VNTSEISLTL NPKLAQVEDP EADVKALFME TKRCILYIIR
VQSGANLMEI MVKPPTEEDE EKWMTLVRDE LSANNTRRSA YSEAHTVVDI ASMTYSELKR
TALENILQLE QTGKIRRDNQ YQDLLNAIAI DIRTKHRRRI QRERELESSR STLARLNDQA
AWLEQQFKTY NDYIEQAMVT LQNKKGKKRF LMPFTKQWDH QRELQKSGKV FKFGSYKYSA
RNLADKGVLV HWKGYTERQW DRVDLTISSN EVGVFTIDGS SGPMMVPGAN AQVPLDDLLQ
AQFNNMQFLD FFEGQLRVNV NLFLHLIMRK FYNE
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