ID Q2U8A9_ASPOR Unreviewed; 477 AA.
AC Q2U8A9;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=N-acetylgalactosaminide beta-1,3-galactosyltransferase {ECO:0000256|ARBA:ARBA00012557};
DE EC=2.4.1.122 {ECO:0000256|ARBA:ARBA00012557};
GN ORFNames=AO090701000504 {ECO:0000313|EMBL:BAE62206.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE62206.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE62206.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-
CC galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-
CC galactosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:15621,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:28257, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:66914, ChEBI:CHEBI:133470; EC=2.4.1.122;
CC Evidence={ECO:0000256|ARBA:ARBA00000862};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T
CC subfamily. {ECO:0000256|ARBA:ARBA00006462}.
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DR EMBL; AP007164; BAE62206.1; -; Genomic_DNA.
DR RefSeq; XP_001823339.1; XM_001823287.1.
DR AlphaFoldDB; Q2U8A9; -.
DR STRING; 510516.Q2U8A9; -.
DR CAZy; GT31; Glycosyltransferase Family 31.
DR EnsemblFungi; BAE62206; BAE62206; AO090701000504.
DR GeneID; 5995396; -.
DR KEGG; aor:AO090701000504; -.
DR VEuPathDB; FungiDB:AO090701000504; -.
DR HOGENOM; CLU_022549_0_0_1; -.
DR OMA; CATFPKH; -.
DR OrthoDB; 2949690at2759; -.
DR Proteomes; UP000006564; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR Gene3D; 3.90.550.50; -; 1.
DR InterPro; IPR026050; C1GALT1/C1GALT1_chp1.
DR InterPro; IPR003378; Fringe-like_glycosylTrfase.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR23033:SF43; -; 1.
DR PANTHER; PTHR23033; BETA1,3-GALACTOSYLTRANSFERASE; 1.
DR Pfam; PF02434; Fringe; 1.
DR Pfam; PF00024; PAN_1; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 188..284
FT /note="Fringe-like glycosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF02434"
FT DOMAIN 392..428
FT /note="Apple"
FT /evidence="ECO:0000259|Pfam:PF00024"
SQ SEQUENCE 477 AA; 54638 MW; 8196BFF887C6E91E CRC64;
MARIILSRKT TNLLVFILFV VIVASVFKIS VPDTSLDPAT LYHHATGHDK NEPDYWEWET
TTRFAPIKNQ FTASSSADDD HLCDSFPTYV LSRIQVVLKI GASEPADRVD AQISTVTRCI
PNLLIVSDRE SELKGHRVHD ILATLPESFR FNVTDLEPYE ALRRGDEKAV GSNEGWYLDR
FKFLPMVERA HETNPTAQWY VFLESDTYYV WDNLFRLLDQ YDPSEPLYFG SPSPGREISQ
GKPMYFAYGG AGFVLSGGAM KKMVHRHHGS MGECIEPSLS LQYEDIVKGD CCGDSVLGWV
LYQKGVKLSG LWPMFNPHPL HSIPFDNAYW CQPVISMHKT MLSDMKGLIE WENQRDRKKP
LLYADLFEYT RMGTFESKPD WDNGDWGGFR EPDESPAHMS MEACRTACHE HAECLSYTYD
HSGHCILVRT MRLGHSKPPT NEVRLSAGWD VSKMRNWRAS HQCEKPMWVK PSITRIF
//
