ID Q2UFY7_ASPOR Unreviewed; 643 AA.
AC Q2UFY7;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Versicolorin B synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AO090026000028 {ECO:0000313|EMBL:BAE59528.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE59528.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE59528.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; AP007159; BAE59528.1; -; Genomic_DNA.
DR RefSeq; XP_001821530.1; XM_001821478.1.
DR AlphaFoldDB; Q2UFY7; -.
DR STRING; 510516.Q2UFY7; -.
DR EnsemblFungi; BAE59528; BAE59528; AO090026000028.
DR GeneID; 5993558; -.
DR KEGG; aor:AO090026000028; -.
DR VEuPathDB; FungiDB:AO090026000028; -.
DR HOGENOM; CLU_002865_6_3_1; -.
DR OMA; REMFYMQ; -.
DR OrthoDB; 858083at2759; -.
DR Proteomes; UP000006564; Chromosome 3.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF138; DEHYDROGENASE PKFF-RELATED; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564}.
FT DOMAIN 75..391
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 496..635
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT BINDING 316
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 577
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 643 AA; 70236 MW; 2A4723F2875455C4 CRC64;
MGRNWFQVTA MAVVPVVGIM AAVNPTILSS AASSLPSLGA MFTSDDFASQ MDGRIQAQGL
LSSHFGMYGW PGQSFDYVIV GGGTAGLAMA RRLSQDGTAS VAVIEAGGFY ETDAGNATEV
PMYLFNYFFD NGKVKNPLFD WYQYTTPQPG LAQREMFYMQ GKTLGGSTAR GAMLYHRGSK
GAYDMWADHV GDDSYRWDKW LPYFQKSVHF SGPETNPRPA NATALNDNTA FTASGGPVHV
GYPFQVNAIS SWVDKALAKM GFPEAQGFSN GNLLGRSYIT HTINPYTRRR ETASSSYLRE
ALMESNNLNI FTRTLVKRVL FDDQNRATGV TVSTDGFEWQ IGAKKEVILS AGVMRSPQLL
MVSGIGPKEH LDQLGIPVRS DLSGVGQNMQ DTIILGPTVP VKVESHSQLM GNKETLPRAI
REYNEQRKGL LTNPGQDYFA FEKHQPGMLK ESTAADIDAA FPDDWPTFSY IALDDTFVPQ
YDGKNYFSMS AALMTPFSRG TVTINSNDTA NPPIVDPQWL ADPRDQEMAV AAFRRCREIV
ASDVMREVVA GPEILPGPQY QTDEEILNYI AETSDAYYAG VGTCAMGKAD DSKAVVDSKA
RVLGVKGLRV VDASIFPFAI DGQPMGTVYA LAEKIAAEMM AEQ
//
