ID Q2UHC8_ASPOR Unreviewed; 1612 AA.
AC Q2UHC8;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=AO090023000496 {ECO:0000313|EMBL:BAE59037.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE59037.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE59037.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
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DR EMBL; AP007157; BAE59037.1; -; Genomic_DNA.
DR STRING; 510516.Q2UHC8; -.
DR EnsemblFungi; BAE59037; BAE59037; AO090023000496.
DR VEuPathDB; FungiDB:AO090023000496; -.
DR HOGENOM; CLU_001696_0_1_1; -.
DR OMA; ATNTCRI; -.
DR OrthoDB; 5477296at2759; -.
DR Proteomes; UP000006564; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:InterPro.
DR GO; GO:0016236; P:macroautophagy; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13980; STKc_Vps15; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045162; Vps15-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17583; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR17583:SF0; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 25..305
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 436..466
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1144..1185
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1482..1505
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 872..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1543..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1392..1408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1612 AA; 179402 MW; E41A82B77F256875 CRC64;
MGQGYSLTTL SAGSAGIDIP ELSDLSYEKS MGGGRFMKSI RARQQNGLVF VKVIMKPFPS
MELEPYVKAI IRERKLLSDV PNALSYQRIL ETGTGGYLVR QYIHSSLYDR MSTRPFPEDI
EKKWIAFQLL CALRDCHALD VFHGDIKTEN VLVTSWNWLY LSDFSSSFKL TFLPEDNPAD
FHFYFDTSGR RTCYLAPERF LEAGEKRESE QVNWAMDIFS AGCVIAELFL ESPIFTLSQM
YKYRKGEYSP EHGQLAKIED PEIRALILHM IQIDPESRYS ADEYLNFWKN KAFPEYFYSF
LHQYMSLMTD PSSGRAQVEA ESANRGEADD RIDRVYLDFD KISYFLGAST KSSKDGSSRT
SSRLTGSTFP VQLDLPQYGH QGPKSQPQTD DGVLIFLTLV VSNLRNTSKA SSRVKACDIL
LAFAERLSDE AKLDRILPYI MILLNDRSDS VRVAAIRSLA QLLEMVHVVS PVNAYLFSEY
IFPRLQPFVS SSNSNPSPLV RAAYASCIAS LAQSSLRFLD MIQALRTDTR LPALIPAGSE
PRWTEDATYH NLYDVARVDL LEYFEAHTKA LLTDSDASVR RAFLGSVSSL CVFFGNLKTN
EVILSHLNTY LNDRDWILKC AFFEAVVGVA AYVGSTSLEQ YILPLMVQSM TDPEEFVVER
VLRSLAAMAD LGLFQRSTTW DLLNITVRFL IHPNVWIREA AVTFVVNSTK FLSVADRYSI
LTPLIRPFLK VNIVGFSEGD ILDALKKPLP RNVYELAFIW ASKVEKGMFW RTAHREGTFS
LGANDGIIPR GSQRSSSYSL SSYSKNEEDE QWLSRLKNMG MGSDDELKLL ALREYIWRVT
ARQVKESENG TSDLNNVIAL TQYGVTPQTV FFDKNQNVKP RRASSAKDQP SKAGERRPHT
ITDALLDAST TIDSRPNSRR KHARSRSHLQ RELGPVLTTP RQDTLDTLRA AESSAASSPV
ASSPSAALGS GPLSPPSSDT ERRLTEGRDS PGHESSSTPT DAENPVVRGL ATGVQRKPSA
ISLLNRKESA KAYAETSTSS ANAFGKVDVP SHRGTPQPSP LSIAHDRKAL ESGPQKYHAS
HSYGGHNPVI LRLLDNVFAE NYPTDFFDLG PYVKEIDTRR AIKKASGYET NKIWKPTGGL
VVIFGEHSGP VNRVVVAPDH AFFVTASDDG TVKIWDTSRL EKNLTPRSRQ TYRHSTEAKI
KSLTFVENTH TFISGATDGS IHAVRVDYNN VNETVRYGKL QLVREYQLSA AEDGTVEYAV
WMEHFRVDAQ STLLIATNTC RVLALDMKTM LPVFSLQNPV HHGTPTTFCC DRKHNWLLIG
TTHGILDLWD LRFRVRLKAW GLPGSSIIHR LQVHPTKGRG RWVCVSSSGS HGNEITVWDI
EKVRCREVYQ TDSPGVGNQA PNSDDAKAKQ TRISSKEYEA WHVDSDRPEG MLSRFATEGP
MSGAIEQGSG PSPSSTPAGI CAFAVGFDAP DDNRDSSTRC GFIVSGGCDR KIRFWDLARP
ELSSIVSGLD VVSESGVAGK PRYEVSQPGP SLLVTSEHFP NSSANAATTG SGGKNNNKKG
TGGRLPRSTV ISLQQQQLLK SHLDFIQDVA ILRVPYGMVV SVDRAGMVYV FQ
//
