ID Q2UK70_ASPOR Unreviewed; 359 AA.
AC Q2UK70;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Isopropylmalate dehydrogenase-like domain-containing protein {ECO:0000259|SMART:SM01329};
GN ORFNames=AO090003000929 {ECO:0000313|EMBL:BAE58045.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE58045.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE58045.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; AP007155; BAE58045.1; -; Genomic_DNA.
DR RefSeq; XP_001820047.1; XM_001819995.2.
DR AlphaFoldDB; Q2UK70; -.
DR STRING; 510516.Q2UK70; -.
DR EnsemblFungi; BAE58045; BAE58045; AO090003000929.
DR GeneID; 5992030; -.
DR KEGG; aor:AO090003000929; -.
DR HOGENOM; CLU_031953_0_1_1; -.
DR OMA; AKQLMGC; -.
DR OrthoDB; 143577at2759; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR InterPro; IPR011829; TTC_DH.
DR NCBIfam; TIGR02089; TTC; 1.
DR PANTHER; PTHR43275; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR PANTHER; PTHR43275:SF2; DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04150)-RELATED; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006564}.
FT DOMAIN 9..351
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 359 AA; 38890 MW; 82DCE2C525E06B72 CRC64;
MASQKPTYRI ASIPGDGIGI EVVDAAIQVV EKLAKTLGTF NIDFTHIPWG TAYYKEHGRY
VSEDCLDTLR KFDAGLFGAV GAPDVPDHIS LWGLLLALRG PLQLYANVRP VRTFPGTKCP
LNTATEGIDW MLVRENSEGE YSGQGGRSHV GQPWEAATEV AMFTRVGIER IMRFAFEVAQ
SRPRKLLTVV TKSNSMRNGM VLWDQVAAEV AKDFPDVTWD KMLVDAMTVR MVAKPQSIDT
IVGTNLHMDI LSDLAAALAG SIGVAPSSNL DPTRKNPSIF EPVHGSAFDI TGKGVANPVA
TFWSAAEMLS WLGEKEAAKQ LMDCVEKVCA AGILTPDLGG TSNTQGVVDA VKKEIERLV
//
