GenomeNet

Database: UniProt
Entry: Q2URJ5
LinkDB: Q2URJ5
Original site: Q2URJ5 
ID   MPH1_ASPOR              Reviewed;        1129 AA.
AC   Q2URJ5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   18-SEP-2019, entry version 91.
DE   RecName: Full=ATP-dependent DNA helicase mph1 {ECO:0000250|UniProtKB:P40562};
DE            EC=3.6.4.12 {ECO:0000250|UniProtKB:P40562, ECO:0000250|UniProtKB:Q9UT23};
DE   AltName: Full=FANCM-like protein 1 {ECO:0000250|UniProtKB:Q9UT23};
GN   Name=mph1 {ECO:0000250|UniProtKB:P40562}; ORFNames=AO090005000804;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G.,
RA   Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K.,
RA   Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W.,
RA   Galagan J.E., Nierman W.C., Yu J., Archer D.B., Bennett J.W.,
RA   Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H.,
RA   Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R.,
RA   Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N.,
RA   Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I.,
RA   Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y.,
RA   Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y.,
RA   Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K.,
RA   Kuhara S., Ogasawara N., Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: ATP-dependent DNA helicase involved in DNA damage repair
CC       by homologous recombination and in genome maintenance. Capable of
CC       unwinding D-loops. Plays a role in limiting crossover recombinants
CC       during mitotic DNA double-strand break (DSB) repair. Component of
CC       a FANCM-MHF complex which promotes gene conversion at blocked
CC       replication forks, probably by reversal of the stalled fork.
CC       {ECO:0000250|UniProtKB:Q9UT23}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000250|UniProtKB:Q9UT23};
CC   -!- SUBUNIT: Interacts with the MHF histone-fold complex to form the
CC       FANCM-MHF complex. {ECO:0000250|UniProtKB:Q9UT23}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40562}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. FANCM sub-subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE55820.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AP007151; BAE55820.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001817822.2; XM_001817770.2.
DR   PRIDE; Q2URJ5; -.
DR   EnsemblFungi; BAE55820; BAE55820; AO090005000804.
DR   GeneID; 5989767; -.
DR   KEGG; aor:AO090005000804; -.
DR   HOGENOM; HOG000076770; -.
DR   KO; K14635; -.
DR   Proteomes; UP000006564; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR039686; FANCM/Mph1-like.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR14025:SF20; PTHR14025:SF20; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1   1129       ATP-dependent DNA helicase mph1.
FT                                /FTId=PRO_0000333367.
FT   DOMAIN      331    499       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      674    843       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     344    351       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       447    450       DEAH box. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COMPBIAS   1033   1036       Poly-Arg.
SQ   SEQUENCE   1129 AA;  126479 MW;  DD55E7B5ED0D7CEE CRC64;
     MTGSDDSSVD YFREGFDDIT DDEFPDATRN AVGSSPRPAK RRRRDGTASD VRRRPSENRE
     SQRYSDGGSP QTGSDSFVVD DDEGNYDELQ SPSQDSYFED AEAPSKYKVF IPKRSNIQEN
     IFVTQLTQPP SPPEMIRGPR WKKPEPSIAR ASTIPTQTIG EGRAAPNAPA ASVDDYDDED
     LNAAIAASLE SFENEQSRPP PSNTKAPTHQ PITRSPTVQN EGATDTSFLL EDIPDDAFDS
     DISLSPPTRA QQQPATRQFG QSSNRPLGVR QTSLFDMTSR NQTDQPPIGE QVWSPPQKDE
     PPTQHKLDHD ALSTWVYPTN LGKTRDYQFN IAQKGLFHNL LVALPTGLGK TFIAATIMLN
     WFRWTESAQI IFVAPTKPLV AQQISACFGI AGIPRSQTTM LTGEAAPGIR AEEWQNKRVF
     FMTPQTLIND LKSGIADPKR IVLLVVDEAH RATGGYAYVE VVKFLRRYNQ SFRVLALTAT
     PGSTVESVQA VIDGLDIARV EIRTEQSLDI REYVHSRNTE VQTFKNSEEM VLCMDLLSKT
     LQPLVDQLRT LNAYWGRDPM MLTAFGLTKS RQQWMASDAG RNAHFGLKGK VNAIFTVLAS
     LAHAIDLLKY HGITPFYRHL LHFQSNTEGQ KGGKYQRQVV QDESFKKLIN HLQPWTKNPE
     FIGHPKLEYL KSVVLNHFMD AGEGSNGEAS DSQSSTRIMI FVHFRDSAEE VTRVLKRYEP
     MIRPHVFVGQ SSAKGSEGMG QKTQLDIVQK FKKGTYNTIV ATSIGEEGLD IGEVDLIVCY
     DSSASPIRML QRMGRTGRKR AGNIVLLLME GKEEESYIKA KDNYEKMQQM IASGSRFTFH
     DDISPRILPA GIRPVADKRH IDIPDENAEQ SLPEPKRRGR APKRPPKKFH MPDNVETGFT
     KASSLTAGPK SKAEKSRKPR TPTPEPVEIP ALEEVVLTSA QQRELEQHYR NIGAASPQFI
     RNPRNDAFPR LQLVARPTKV VKHGSLTRRM IGTLQKMNNV GPDCGDRFKK ILALESARQG
     DSVIPNRSPR HERRRRLSKT KPRYNHLSTS VDKETLSTED SQLVTPEHLL SSVVKGQKQQ
     PFYSSQRSKD DDSDDNFDPP DLATLLTRSA ERNNAHKTSR FVVSDDSDD
//
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