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Database: UniProt
Entry: Q2UTN6
LinkDB: Q2UTN6
Original site: Q2UTN6 
ID   SET2_ASPOR              Reviewed;         965 AA.
AC   Q2UTN6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   10-APR-2019, entry version 94.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain-containing protein 2;
GN   Name=set2; ORFNames=AO090009000660;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G.,
RA   Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K.,
RA   Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W.,
RA   Galagan J.E., Nierman W.C., Yu J., Archer D.B., Bennett J.W.,
RA   Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H.,
RA   Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R.,
RA   Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N.,
RA   Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I.,
RA   Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y.,
RA   Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y.,
RA   Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K.,
RA   Kuhara S., Ogasawara N., Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Histone methyltransferase that methylates histone H3 to
CC       form H3K36me. Involved in transcription elongation as well as in
CC       transcription repression (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00901};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- DOMAIN: The AWS and SET domains are necessary for transcription
CC       repression. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SET2 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00901}.
DR   EMBL; AP007150; BAE55079.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q2UTN6; -.
DR   SMR; Q2UTN6; -.
DR   PRIDE; Q2UTN6; -.
DR   EnsemblFungi; BAE55079; BAE55079; AO090009000660.
DR   HOGENOM; HOG000172130; -.
DR   OMA; NHACGED; -.
DR   Proteomes; UP000006564; Chromosome 1.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IEA:InterPro.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1740.100; -; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR025788; Hist-Lys_N-MeTrfase_SET2_fun.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51568; SAM_MT43_SET2_1; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   3: Inferred from homology;
KW   Chromosome; Complete proteome; Methyltransferase; Nucleus;
KW   Reference proteome; Repressor; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN         1    965       Histone-lysine N-methyltransferase, H3
FT                                lysine-36 specific.
FT                                /FTId=PRO_0000269781.
FT   DOMAIN      150    223       AWS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00562}.
FT   DOMAIN      225    342       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN      349    365       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   DOMAIN      615    646       WW. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00224}.
FT   COMPBIAS    647    655       Poly-Pro.
FT   COMPBIAS    692    808       Lys-rich.
FT   COMPBIAS    878    932       Pro-rich.
SQ   SEQUENCE   965 AA;  109182 MW;  BAE272D48E1C9069 CRC64;
     MSPHDYADRR SESVTDAVTA MNLEPDRATD TPALNGGSTS LKDDTNGVSR SPSAQNMDVA
     VKSRSSSQTP VKKEEETSNT ADMEEKVGGD ITVKQEPGQP PKLTRSSSQK VVARPPQLFS
     HLRDSTAEAR VSFELMDSCT YANKYMGYTE HAMECDCAEE WVSSVSGNIL SMPISLYALE
     PALSKNLACG EDSDCINRAT KIECVGDCGC GPDCQNQRFQ RKEYAQVAVI KTEKKGFGLR
     AEADLRPHQF IYEYVGEVIN EGQFRRRMRQ YDEEGIKHFY FMSLSKGEFV DATKRGNLGR
     FCNHSCNPNC YVDKWVVGEK LRMGIFAERD IQAGEELVFN YNVDRYGADP QPCYCGEPNC
     TGFIGGRTQT ERATKLSNAT IEALGIEDAD GWDTAVAKRP RKKKMGEDDE EYVDSVQPKS
     LEENGVTKVM AALMQCQEKW IAVKLLGRIQ RCDDERVRNR VVKMHGYQIL NSQLTMWKDD
     FNVVLQILDI LDKFPRLTRN KIIDSKIEVT IQPLTSCGDE RVEKRAATLL QVWSTLEVGY
     RIPRMKRDPN ATAQAVNQFE RRETIRDQRR RSKSRSRSRS RSIEAPRGPA AQTRGVYGQR
     NPHHHGPRSF RRQFNPLPTG WFAAESNGRT YYYSARGDTT WTRPTKPAPQ PPPPPKESRD
     KALQDIIDGI MNAKENTPKE KSGTPGTPQV SKPIPVKKEG QEKWRGYSED KQKKVYENTL
     FPHIKYVVDK FKHKLPKEDL KRYAKDVAKK LVNSDFKNNR VEDPTKISEK QQKKVKKYCK
     EFFDKAVLKH RAYEQRKYEK QAKGMDSKVE TPQAPSDDEA LDVKMSDDEE DKADEKDTPM
     TAEETQGGTK RKREGGIAED SNLGEYISSS KRQRSSTPPP LPPISPGDDP QNMDNAKKIL
     RDDIDSRSEN NEFTPPPPPP PPPDDEMPSE SPETDHAIDQ SPSRAEYITD MNKLKSSQPE
     IEGKV
//
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