ID ACRB_ASPOR Reviewed; 1013 AA.
AC Q2UUI0;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 2.
DT 22-FEB-2023, entry version 57.
DE RecName: Full=Probable ubiquitination network signaling protein acrB;
DE AltName: Full=Acriflavine resistance protein B;
GN Name=acrB; Synonyms=acr2; ORFNames=AO090009000307;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Component of the regulatory network controlling carbon source
CC utilization through ubiquitination and deubiquitination involving creA,
CC creB, creC, creD and acrB. Involved in resistance to acriflavine, and
CC required for normal growth on a range of sole carbon sources, including
CC fructose, cellobiose, raffinose, and starch, and reduced utilization of
CC amino acids, including GABA and beta-alanine, as sole carbon and
CC nitrogen sources (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the acrB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE54785.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AP007150; BAE54785.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q2UUI0; -.
DR SMR; Q2UUI0; -.
DR STRING; 510516.Q2UUI0; -.
DR EnsemblFungi; BAE54785; BAE54785; AO090009000307.
DR VEuPathDB; FungiDB:AO090009000307; -.
DR OrthoDB; 2720659at2759; -.
DR Proteomes; UP000006564; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR PROSITE; PS00589; PTS_HPR_SER; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Ubl conjugation pathway.
FT CHAIN 1..1013
FT /note="Probable ubiquitination network signaling protein
FT acrB"
FT /id="PRO_0000395730"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 596..782
FT /evidence="ECO:0000255"
FT COMPBIAS 108..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 109286 MW; 6967670D69EFE933 CRC64;
MPRSSATARK SHSNRQENGA AGSGKKVNKQ KSNGQLNGNA NGSSAPISGP SSQVDWPSSR
SNSDTAINST VATATKANGT TECSKADGNG RGYLNGYVKG NPDMSYGQAN GAVPQNGGLT
GQASRRTESS KRSGSNTSIN PLQLASTILK SCPMYDTIAI LIFLLQLPPM VLTLVQFLFA
SLTFMPPGGA SAGSLTSNFD IFQGPAGTPS LGTMIAMDGF FLLFWGLFMW TWAQNFALDL
AHVQVAITLG GGGSGKNGGV NTLCVGIVLV LHLIRSKGIQ DFVLGHLLSA KVISPDLLSQ
YSHLLPSEFR RTEPQSSPSW IRSLLAVHIL AQAGTAMARR SMAKNRAPAP PRTGKRVDTE
ASAGSQTQID SAFESGTSVS SYIGADGQLI TPATHKDGRD RLISAKKRRR QANQVRNRQP
FWAALASTKV TVMREYEHSR ALSKTARGLT MTEEDLQGVS LDDGLVWITD VDSSSIKFAA
GDLVSEDAGV SGSCESGRLG EDMEPFYVCV NGALWATVTI CKVQDVAKGS SVVHWRGEIS
GLAPNCAYTC SFLRSDTEEE ICVMSVKTPI ANDAEQVVSS VSTPPQPSYR PSSPTTTLKN
SIVNAELKLN EKRTRLRKAK NDHKLVVSKI RKELDNYNHR LHSGTDENRQ KQRSLQLERN
IKQTEEATAV LEVQLDNLEN IPEEELEEWS AEKAKYEHEL ELFNSAKEDV ATARSAAARE
VSQLESDLTS TIQRRERLQG RRTRVNEQYE RIISANAQGL NERERRAAEQ FAREQDQAKV
EANFNEQFAS ISQSVQEYQL RTNQLWQQCV AIEQALQQQQ QQQILLDSAP LTPEGNLPGT
NTLSEAPTLS LGALTTSASS NRSLLGLSFP PLKSSPLQHA SSPIGPTSSR PTSPTQAPSY
LQHFPASPLI NTASPFESDF IHRDRSFSNR SGHSSLYGSD FFDSGRRPPF QFDLSEKVVD
KRRSSGSESN APNLGLRPIC SPFPRAGSRA SGSGSGGSGS GSGSPSSATG KGN
//
