ID FEZF2_BOVIN Reviewed; 458 AA.
AC Q2VWH6; Q2VWH7;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=Fez family zinc finger protein 2;
DE AltName: Full=Forebrain embryonic zinc finger-like protein 2;
DE AltName: Full=Zinc finger protein 312;
DE AltName: Full=Zinc finger protein Fez-like;
GN Name=FEZF2; Synonyms=FEZL, ZNF312;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND VARIANT GLY-116 INS.
RC TISSUE=Forebrain;
RX PubMed=16611727; DOI=10.1073/pnas.0601015103;
RA Sugimoto M., Fujikawa A., Womack J.E., Sugimoto Y.;
RT "Evidence that bovine forebrain embryonic zinc finger-like gene influences
RT immune response associated with mastitis resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:6454-6459(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hippocampus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription repressor. Binds to 5'GCAG-3' core sequence.
CC Required for the specification of corticospinal motor neurons and other
CC subcerebral projection neurons. May play a role in layer and neuronal
CC subtype-specific patterning of subcortical projections and axonal
CC fasciculation. Controls the development of dendritic arborization and
CC spines of large layer V pyramidal neurons (By similarity). May be
CC responsible for mastitis resistance and innate immunity. {ECO:0000250,
CC ECO:0000269|PubMed:16611727}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16611727}.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain and weakly in the mammary
CC gland. Infection enhances expression in the mammary gland and promotes
CC expression of SEMA5A. {ECO:0000269|PubMed:16611727}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AY644769; AAV85457.1; -; mRNA.
DR EMBL; AY644770; AAV85458.1; -; mRNA.
DR EMBL; BC123390; AAI23391.1; -; mRNA.
DR RefSeq; NP_001033287.1; NM_001038198.2.
DR RefSeq; XP_010815953.1; XM_010817651.2.
DR AlphaFoldDB; Q2VWH6; -.
DR SMR; Q2VWH6; -.
DR STRING; 9913.ENSBTAP00000027056; -.
DR PaxDb; 9913-ENSBTAP00000027056; -.
DR GeneID; 613683; -.
DR KEGG; bta:613683; -.
DR CTD; 55079; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_021813_2_1_1; -.
DR InParanoid; Q2VWH6; -.
DR OrthoDB; 2896453at2759; -.
DR TreeFam; TF316780; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24394:SF45; ZINC FINGER PROTEIN 771; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Neurogenesis; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..458
FT /note="Fez family zinc finger protein 2"
FT /id="PRO_0000295120"
FT ZN_FING 276..298
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 304..326
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 332..354
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 360..382
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..410
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 416..439
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 26..41
FT /note="Engrailed homology 1 repressor"
FT /evidence="ECO:0000250"
FT VARIANT 116
FT /note="G -> GG (associated with susceptibility to
FT mastitis)"
FT /evidence="ECO:0000269|PubMed:16611727"
SQ SEQUENCE 458 AA; 48842 MW; D947CDB723FA6F11 CRC64;
MASSASLETM VPPACPRAGA SPATSKTLAF SIERIMAKTS EPRAPFEPRP GALEADSGQG
KKLLNLCSPL PCMIPLQPLG YEMPSKTLLS YSELWKSSLR AGGSGGGGGG GGGGGGAPVC
GASGLCKTNC GVCCKAELGL VPSALPAGRV IKPQVINQAV GLPASGSLYY FNYLDSATYP
SSELLGGHLF PSGLLNTQAP AALAAHPKLF LLENAKLAGL TADKFAHPAP YAHKERLPAP
LEQVLKENSA LTAERGGVKG HSKLPGGSAD GKPKNFTCEV CGKVFNAHYN LTRHMPVHTG
ARPFVCKVCG KGFRQASTLC RHKIIHTQEK PHKCNQCGKA FNRSSTLNTH IRIHAGYKPF
VCEFCGKGFH QKGNYKNHKL THSGEKQYKC TICNKAFHQV YNLTFHMHTH NDKKPFTCAT
CGKGFCRNFD LKKHVRKLHD SVGPAAPSTK DLTRTVQS
//
