ID SVOP_XENLA Reviewed; 548 AA.
AC Q2XWK0;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Synaptic vesicle 2-related protein;
DE Short=SV2-related protein;
GN Name=svop;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=16217738; DOI=10.1002/dvdy.20618;
RA Logan M.A., Steele M.R., Vetter M.L.;
RT "Expression of synaptic vesicle two-related protein SVOP in the developing
RT nervous system of Xenopus laevis.";
RL Dev. Dyn. 234:802-807(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in embryonic trigeminal ganglion and
CC spinal cord. {ECO:0000269|PubMed:16217738}.
CC -!- DEVELOPMENTAL STAGE: Expression increases continuously throughout
CC embryonic development. First detected in embryos at day 12.
CC {ECO:0000269|PubMed:16217738}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; DQ167576; ABA54609.1; -; mRNA.
DR RefSeq; NP_001089190.1; NM_001095721.1.
DR AlphaFoldDB; Q2XWK0; -.
DR SMR; Q2XWK0; -.
DR GeneID; 734235; -.
DR KEGG; xla:734235; -.
DR AGR; Xenbase:XB-GENE-939909; -.
DR CTD; 734235; -.
DR Xenbase; XB-GENE-939909; svop.L.
DR OMA; GAFIWLP; -.
DR OrthoDB; 2084713at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 734235; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17441; MFS_SVOP; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR047969; SVOP-like_MFS_dom.
DR PANTHER; PTHR23511; SYNAPTIC VESICLE GLYCOPROTEIN 2; 1.
DR PANTHER; PTHR23511:SF5; TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03500)-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Membrane; Reference proteome; Synapse; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..548
FT /note="Synaptic vesicle 2-related protein"
FT /id="PRO_0000279456"
FT TOPO_DOM 1..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..119
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..180
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..238
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..373
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..401
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 423..424
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 446..457
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 479..486
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 508..548
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 519..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 60995 MW; 89B6F9EAFF5F4D48 CRC64;
MEDDLFQLRH LPVVKFRRTG ESSKSEDDNI SGEHEIQIGP VQTELEAVEL EDGTTVPKEF
ANPTDDTFMV EDAVEAIGFG KFQWKLSMLT GLAWMADAME MMILSILAPQ LHCEWRLPSW
QVALLTSVVF IGMMASSSLW GNVSDQYGRR TGLKISVIWT LYYGILSAFA PVYSWILVLR
GLVGFGIGGV PQSVTLYAEF LPMKSRAKCI LLIEIFWALG TVFEVLLAIF VMPTLGWRWL
LILSALPLML FAILCFWLPE SARYEVLSGN QEKALATLKR IATENGAPMP LGKLIVSRQE
DRGKIRDLFS PQFRCTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI SNQRKAVKPK
CSLACEYLTV EDYTDLLWTT LSEFPGLLVT LWIIDRVGRK KTMAICFIIF SFSALLLFLC
VGRNVLTVFL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ
VMLESSIYLT VLVYSGCCVL AAVASCFLPI ETKGRGLQES SHREWGQEMV GRGTHNVGAT
PSHSGSQE
//
