ID Q2YCG2_NITMU Unreviewed; 772 AA.
AC Q2YCG2;
DT 20-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Heparinase II/III-like protein {ECO:0000313|EMBL:ABB73559.1};
GN OrderedLocusNames=Nmul_A0251 {ECO:0000313|EMBL:ABB73559.1};
GN ORFNames=SAMN05216403_11035 {ECO:0000313|EMBL:SEF81274.1};
OS Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosospira.
OX NCBI_TaxID=323848 {ECO:0000313|EMBL:ABB73559.1, ECO:0000313|Proteomes:UP000002718};
RN [1] {ECO:0000313|EMBL:ABB73559.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 25196 {ECO:0000313|EMBL:ABB73559.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Lykidis A., Richardson P.;
RT "Complete sequence of Chromosome 1 of Nitrosospira multiformis ATCC
RT 25196.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25196 / NCIMB 11849 / C 71
RC {ECO:0000313|Proteomes:UP000002718};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC
RT 25196.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ABB73559.1, ECO:0000313|Proteomes:UP000002718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25196 {ECO:0000313|EMBL:ABB73559.1}, and ATCC 25196 /
RC NCIMB 11849 / C 71 {ECO:0000313|Proteomes:UP000002718};
RX PubMed=18390676; DOI=10.1128/AEM.02722-07;
RA Norton J.M., Klotz M.G., Stein L.Y., Arp D.J., Bottomley P.J., Chain P.S.,
RA Hauser L.J., Land M.L., Larimer F.W., Shin M.W., Starkenburg S.R.;
RT "Complete genome sequence of Nitrosospira multiformis, an ammonia-oxidizing
RT bacterium from the soil environment.";
RL Appl. Environ. Microbiol. 74:3559-3572(2008).
RN [4] {ECO:0000313|EMBL:SEF81274.1, ECO:0000313|Proteomes:UP000236751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nl13 {ECO:0000313|EMBL:SEF81274.1,
RC ECO:0000313|Proteomes:UP000236751};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
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DR EMBL; CP000103; ABB73559.1; -; Genomic_DNA.
DR EMBL; FNVK01000010; SEF81274.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2YCG2; -.
DR STRING; 323848.Nmul_A0251; -.
DR CAZy; PL15; Polysaccharide Lyase Family 15.
DR KEGG; nmu:Nmul_A0251; -.
DR eggNOG; COG5652; Bacteria.
DR HOGENOM; CLU_362017_0_0_4; -.
DR OrthoDB; 9772435at2; -.
DR Proteomes; UP000002718; Chromosome.
DR Proteomes; UP000236751; Unassembled WGS sequence.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.70; -; 1.
DR Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008929; Chondroitin_lyas.
DR InterPro; IPR012480; Hepar_II_III.
DR InterPro; IPR032518; HepII_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR012364; Oligosacch_lyase.
DR PANTHER; PTHR39210; HEPARIN-SULFATE LYASE; 1.
DR PANTHER; PTHR39210:SF1; HEPARIN-SULFATE LYASE; 1.
DR Pfam; PF16332; DUF4962; 1.
DR Pfam; PF07940; Hepar_II_III; 1.
DR PIRSF; PIRSF034409; Oligosach_lyase; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW Reference proteome {ECO:0000313|Proteomes:UP000002718};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 95..469
FT /note="Heparinase II N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16332"
FT REGION 696..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 86404 MW; DA85F231EAE6FB3B CRC64;
MFRKPTLQAL AVASLLAHTQ VGCQQLPPEK IDNRMSDWAE PTAAEQIPVT PANGAIVKQN
PPDFDWRRIN LSAEYVLVLQ HEGGKRYEWR TPRNWYLPSA SLPPGKYSWQ VRPIGPGSGV
GESAWRRFTI SEDAIPFVVP DNEDLLRELR NKPRPRSFVR GKDESKSRSL VQSERSNVVA
TVKNQVKKKM AQPALAAPPK LVDRKVGKGA GWANSLFAIR NYVSGEAYQL RATAFLWQLN
HDPALLAEAL RTGDALAALD PNGPTGHKSQ DQASRDIAIG LASAFDWLGD AVPAESQQLW
LKAIAARGQA IYDDLLGGQR RFELARYDSH GWTNLGYLAD LSALMVGTLP VADNWFNDSF
RFYIHTVSPW GGEEGGWANS SAYAIWSLNL GIIPRWDSIR AATGINIYKK PWSQGLLKYF
VYFEPPSSPI QLFGDGAEMP PDFSQIKGYA SRQDSPLAAW YFLNIDKREY PLQVLEAPIP
LPVEGIKPEP PRANSIAFHD IGWVAMHSAI VDPLRTSVYF RSSPYAAFGH SHADNNSFVL
VSRDEPLLIA SGYYDWEGSP HWKQWYWQTK AHNAITFDGG KGQAEKTGSG KMTAKGQLTE
FQSNGKVDFT EGDATPAYEG ALQQARRRLW YLRNKNVLII HDSLRSATPR QFEWNIHALN
PFEIKEPGSI EVKQKAARAC INMLQPHAIE FAQNNRFDAP PQIPPSRNEN DQGGARTTND
QWHGRFQTKE RMAAVEFLAV VDIDCKNIPI EMGNFESNRK IKVGDESIHV AR
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