ID   Q2YII7_BRUA2            Unreviewed;       270 AA.
AC   Q2YII7;
DT   07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   07-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=Pyruvate dehydrogenase complex repressor {ECO:0000256|ARBA:ARBA00039592};
GN   OrderedLocusNames=BAB2_0172 {ECO:0000313|EMBL:CAJ12338.1};
OS   Brucella abortus (strain 2308).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391 {ECO:0000313|EMBL:CAJ12338.1, ECO:0000313|Proteomes:UP000002719};
RN   [1] {ECO:0000313|EMBL:CAJ12338.1, ECO:0000313|Proteomes:UP000002719}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308 {ECO:0000313|EMBL:CAJ12338.1,
RC   ECO:0000313|Proteomes:UP000002719};
RX   PubMed=16299333; DOI=10.1128/IAI.73.12.8353-8361.2005;
RG   Microbial Genomics Group;
RG   Lawrence Livermore National Laboratory;
RG   and the Genome Analysis Group;
RG   Oak Ridge National Laboratory;
RA   Chain P., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: Transcriptional repressor for the pyruvate dehydrogenase
CC       complex genes aceEF and lpd. {ECO:0000256|ARBA:ARBA00037357}.
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DR   EMBL; AM040265; CAJ12338.1; -; Genomic_DNA.
DR   RefSeq; WP_002966404.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YII7; -.
DR   STRING; 359391.BAB2_0172; -.
DR   GeneID; 58777879; -.
DR   KEGG; bmf:BAB2_0172; -.
DR   PATRIC; fig|359391.11.peg.2120; -.
DR   HOGENOM; CLU_017584_9_5_5; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.20.120.530; GntR ligand-binding domain-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43537:SF34; PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR; 1.
DR   PANTHER; PTHR43537; TRANSCRIPTIONAL REGULATOR, GNTR FAMILY; 1.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF48008; GntR ligand-binding domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002719};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          12..80
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50949"
SQ   SEQUENCE   270 AA;  30291 MW;  8FBBDFD9542A9D6B CRC64;
     MADTVFSRIQ ASRTADDVVH QIESLILEGV LRGGDRLPGE RELARQFDIS RPILRDALKR
     LETAGLLTSR HGGGTFVADV IGQVFSAPVV KLFADHHKAT ADYLEYRREI ESVAAEYAAL
     RATPADRALL TEIMNAMEKA HGADDFATEA RLDVELHNAI GEAAHNIVLL HTLRSCYQLL
     KDGVFYNRSV IYNHPGVADV FLSQHRAIYD AVMAGNPQAA REAVQKHIRF VEQATHDRAL
     NDERERVARL RYRQRAGSKE LKEIREDESE
//