ID Q30QR2_SULDN Unreviewed; 237 AA.
AC Q30QR2;
DT 06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=adenosylhomocysteine nucleosidase {ECO:0000256|ARBA:ARBA00011974};
DE EC=3.2.2.9 {ECO:0000256|ARBA:ARBA00011974};
GN OrderedLocusNames=Suden_1392 {ECO:0000313|EMBL:ABB44669.1};
OS Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira
OS denitrificans (strain ATCC 33889 / DSM 1251)).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Sulfurimonadaceae; Sulfurimonas.
OX NCBI_TaxID=326298 {ECO:0000313|EMBL:ABB44669.1, ECO:0000313|Proteomes:UP000002714};
RN [1] {ECO:0000313|EMBL:ABB44669.1, ECO:0000313|Proteomes:UP000002714}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33889 / DSM 1251 {ECO:0000313|Proteomes:UP000002714};
RX PubMed=18065616; DOI=10.1128/AEM.01844-07;
RA Sievert S.M., Scott K.M., Klotz M.G., Chain P.S.G., Hauser L.J., Hemp J.,
RA Huegler M., Land M., Lapidus A., Larimer F.W., Lucas S., Malfatti S.A.,
RA Meyer F., Paulsen I.T., Ren Q., Simon J., Bailey K., Diaz E.,
RA Fitzpatrick K.A., Glover B., Gwatney N., Korajkic A., Long A.,
RA Mobberley J.M., Pantry S.N., Pazder G., Peterson S., Quintanilla J.D.,
RA Sprinkle R., Stephens J., Thomas P., Vaughn R., Weber M.J., Wooten L.L.;
RT "Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas
RT denitrificans.";
RL Appl. Environ. Microbiol. 74:1145-1156(2008).
RN [2] {ECO:0007829|PDB:4JWT}
RP X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 2-237 IN COMPLEX WITH ADENINE.
RA Sampathkumar P., Gizzi A., Ahmed M., Banu N., Bhosle R., Bonanno J.,
RA Chamala S., Chowdhury S., Fiser A., Glenn A.S., Hammonds J., Hillerich B.,
RA Khafizov K., Lafleur J., Suarez J., Haapalainen A., Love J.D., Stead M.,
RA Seidel R., Toro R., Schramm V.L., Almo S.C.;
RT "Crystal structure of a putative 5'-methylthioadenosine/S-
RT adenosylhomocysteine nucleosidase from Sulfurimonas denitrificans DSM
RT 1251.";
RL Submitted (MAR-2013) to the PDB data bank.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
CC pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-
CC thioadenosine (hydrolase route): step 1/2.
CC {ECO:0000256|ARBA:ARBA00004945}.
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DR EMBL; CP000153; ABB44669.1; -; Genomic_DNA.
DR RefSeq; WP_011373021.1; NC_007575.1.
DR PDB; 4JWT; X-ray; 2.05 A; A=2-237.
DR PDBsum; 4JWT; -.
DR AlphaFoldDB; Q30QR2; -.
DR SMR; Q30QR2; -.
DR STRING; 326298.Suden_1392; -.
DR KEGG; tdn:Suden_1392; -.
DR eggNOG; COG0775; Bacteria.
DR HOGENOM; CLU_031248_2_0_7; -.
DR OrthoDB; 9792278at2; -.
DR UniPathway; UPA00904; UER00871.
DR Proteomes; UP000002714; Chromosome.
DR GO; GO:0008782; F:adenosylhomocysteine nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008930; F:methylthioadenosine nucleosidase activity; IEA:InterPro.
DR GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IEA:UniProtKB-UniPathway.
DR GO; GO:0009164; P:nucleoside catabolic process; IEA:InterPro.
DR CDD; cd09008; MTAN; 1.
DR Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR InterPro; IPR010049; MTA_SAH_Nsdase.
DR InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR NCBIfam; TIGR01704; MTA_SAH-Nsdase; 1.
DR PANTHER; PTHR46832; 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR PANTHER; PTHR46832:SF1; 5'-METHYLTHIOADENOSINE_S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR Pfam; PF01048; PNP_UDP_1; 1.
DR SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4JWT};
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Glycosidase {ECO:0000313|EMBL:ABB44669.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ABB44669.1};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Reference proteome {ECO:0000313|Proteomes:UP000002714}.
FT DOMAIN 2..225
FT /note="Nucleoside phosphorylase"
FT /evidence="ECO:0000259|Pfam:PF01048"
FT BINDING 152
FT /ligand="adenine"
FT /ligand_id="ChEBI:CHEBI:16708"
FT /evidence="ECO:0007829|PDB:4JWT"
FT BINDING 196
FT /ligand="adenine"
FT /ligand_id="ChEBI:CHEBI:16708"
FT /evidence="ECO:0007829|PDB:4JWT"
SQ SEQUENCE 237 AA; 25541 MW; D9B151442E5BB10D CRC64;
MKIAIMGAMP EEISPILEKI GSYKSTSYAG NKYYEATYQG VELVIAYSKI GKVFSALSAA
TMIEHFGATK LLFSGVAGAI STNLKVGDLI VATKLSQHDL DITAFGHPYG YVPEGSVFVE
ADKDMIELSK KVALEMGKSV QEGIIATGDQ FVANEERKNW IGTTFGADAL EMEGGSVGVV
CNALNIPFFI LRSISDAADM DASFSFDEFL ESSAKESAEF IMKMVDELVA LPLQDIK
//
