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Database: UniProt
Entry: Q30ZK3
LinkDB: Q30ZK3
Original site: Q30ZK3 
ID   UVRB_DESAG              Reviewed;         682 AA.
AC   Q30ZK3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   18-SEP-2019, entry version 92.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204};
GN   OrderedLocusNames=Dde_2096;
OS   Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans
OS   (strain G20)).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=207559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G20;
RX   PubMed=21685289; DOI=10.1128/jb.05400-11;
RA   Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L.,
RA   Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C.,
RA   Tapia R., Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A.,
RA   Lucas S., Nolan M., Lapidus A.L., Palumbo A.V., Wall J.D.;
RT   "Complete genome sequence and updated annotation of Desulfovibrio
RT   alaskensis G20.";
RL   J. Bacteriol. 193:4268-4269(2011).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
DR   EMBL; CP000112; ABB38893.1; -; Genomic_DNA.
DR   RefSeq; WP_011367997.1; NC_007519.1.
DR   SMR; Q30ZK3; -.
DR   STRING; 207559.Dde_2096; -.
DR   EnsemblBacteria; ABB38893; ABB38893; Dde_2096.
DR   KEGG; dde:Dde_2096; -.
DR   eggNOG; ENOG4105CCW; Bacteria.
DR   eggNOG; COG0556; LUCA.
DR   HOGENOM; HOG000073580; -.
DR   KO; K03702; -.
DR   OMA; RYMHSEI; -.
DR   OrthoDB; 95696at2; -.
DR   BioCyc; DALA207559:G1G52-1969-MONOMER; -.
DR   Proteomes; UP000002710; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR041471; UvrB_inter.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome;
KW   SOS response.
FT   CHAIN         1    682       UvrABC system protein B.
FT                                /FTId=PRO_0000227310.
FT   DOMAIN       27    414       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      432    594       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      642    677       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      40     47       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF        93    116       Beta-hairpin.
SQ   SEQUENCE   682 AA;  77705 MW;  EEBDA8694604F934 CRC64;
     MQDSVFRIES EYVPRGDQPE AITQLSDNIR AGVAHQVLLG VTGSGKTFTM AHTIERCQRP
     ALILAPNKTL AAQLYNEFRA LFPHNAVEYF VSYYDYYQPE AYVPTSDTYI EKDSSINDNI
     DKLRHAATHA LLTRRDVIII ASVSCIYGLG SPEYYAKMVI PVEAGQHMSM DSLIGRLVDV
     QYERNDYDFH RGTFRVRGDV LEVIPAYHHE RALRLEFFGD EIDSIKEIDP LTGNVLGDVG
     KTVIYPASHY VSDRDNLNRA VSDIREELRL RLEEYRQGNR LVEAQRLEQR TMLDLEMIEE
     MGYCTGIENY SRHLDGRTAG EPPACLLDYF PDNFILFVDE SHITVSQVGA MYKGDRSRKQ
     TLVDFGFRLP SALDNRPLEF SEFEKRLNQV VYVSATPSRW ELDRSEGIVV EQIIRPTGLL
     DPLTEVRPTK GQMEDLMTEC RSRTARDERV LVTTLTKRMA EDLTEYLTSM GVSARYLHSD
     IDTMERMAII QALRRKEFDV LVGINLLREG LDIPEVSLVA ILDADKEGFL RSTGSLIQTF
     GRAARNVDGR VIMYADSVTR SMTAAMQETE RRREKQRLYN EEHGIEPVSV RKSLETPFDT
     LYSDARSAAA KGRGKGRGRQ AAPAQTAAED TTAYGISAEE LGGLIQRLER EMRESARDLE
     FEKAAELRDR IRMLRERLLQ QD
//
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