ID Q31EW4_HYDCU Unreviewed; 352 AA.
AC Q31EW4;
DT 06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase {ECO:0000313|EMBL:ABB42309.1};
DE EC=1.1.1.34 {ECO:0000313|EMBL:ABB42309.1};
GN OrderedLocusNames=Tcr_1717 {ECO:0000313|EMBL:ABB42309.1};
OS Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) (Thiomicrospira
OS crunogena).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Hydrogenovibrio.
OX NCBI_TaxID=317025 {ECO:0000313|EMBL:ABB42309.1};
RN [1] {ECO:0000313|EMBL:ABB42309.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=XCL-2 {ECO:0000313|EMBL:ABB42309.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Lykidis A., Scott K.M., Sievert S., Kerfeld C.,
RA Freyermuth S., Dobrinski K., Boller A., Fitzpatrick K., Thoma P., Moore J.,
RA Richardson P.;
RT "Complete sequence of Thiomicrospira crunogena XCL-2.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; CP000109; ABB42309.1; -; Genomic_DNA.
DR AlphaFoldDB; Q31EW4; -.
DR STRING; 317025.Tcr_1717; -.
DR KEGG; tcx:Tcr_1717; -.
DR eggNOG; COG1257; Bacteria.
DR HOGENOM; CLU_001734_2_1_6; -.
DR OrthoDB; 9794902at2; -.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABB42309.1}.
SQ SEQUENCE 352 AA; 37836 MW; 4BA0C4FEA4D03C24 CRC64;
MKNESLRNFA HIPMQSVGPF KLIGEVETDD LMVPMATYET PLWPSVARGA RVTHHAGGIR
VTVIDERMTR SVLLEAPNAS IALQRFQALK ADQAALQAIV SQSSQYAKLL DLNVQIIGNL
IYLRLEFSTG DASGHNMVTN AADKLIPWIL ESYPDLSYVS ISGNYCTDKK VSAVNGILGR
GKNVVCETTI PRKLCQRFLK TTPEAIVDLH IKKDLIGSIV SGGLRTANAH VANMLLGFYL
ATGQDAANII EGSQAINHIE VNADGDLYFS TTLPNLIVGT VGNGKGLDFV LDNLEQLGCV
DQTAKPGQNA RRLACIAGAT ALCGELSLLA AQTNPGELMS AHLKLERQNA SS
//
