ID WDR70_BOVIN Reviewed; 652 AA.
AC Q32LB0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=WD repeat-containing protein 70;
GN Name=WDR70;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat GAD-1 family. {ECO:0000305}.
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DR EMBL; BC109667; AAI09668.1; -; mRNA.
DR RefSeq; NP_001069706.1; NM_001076238.2.
DR AlphaFoldDB; Q32LB0; -.
DR SMR; Q32LB0; -.
DR STRING; 9913.ENSBTAP00000068018; -.
DR PaxDb; 9913-ENSBTAP00000044228; -.
DR GeneID; 540724; -.
DR KEGG; bta:540724; -.
DR CTD; 55100; -.
DR eggNOG; KOG0772; Eukaryota.
DR InParanoid; Q32LB0; -.
DR OrthoDB; 5480020at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16017; GASTRULATION DEFECTIVE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR16017:SF0; WD REPEAT-CONTAINING PROTEIN 70; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Isopeptide bond; Phosphoprotein; Reference proteome; Repeat;
KW Ubl conjugation; WD repeat.
FT CHAIN 1..652
FT /note="WD repeat-containing protein 70"
FT /id="PRO_0000305143"
FT REPEAT 178..217
FT /note="WD 1"
FT REPEAT 225..266
FT /note="WD 2"
FT REPEAT 279..319
FT /note="WD 3"
FT REPEAT 328..367
FT /note="WD 4"
FT REPEAT 374..413
FT /note="WD 5"
FT REPEAT 419..464
FT /note="WD 6"
FT REPEAT 467..506
FT /note="WD 7"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 450
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT MOD_RES 577
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT MOD_RES 619
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT MOD_RES 636
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT CROSSLNK 294
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT CROSSLNK 588
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT CROSSLNK 594
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NW82"
SQ SEQUENCE 652 AA; 72641 MW; CBA88E3246EBF80A CRC64;
MERPGPSDGS DASGPDPQLA VTMGFTGFGK KARTFDLEAM FEQTRRTAVE RSRKTLEARE
REEEMNREKE LRRQNEDLEP TSSGSNVARA CSKSSSRDTS SSESDESSDS SDDELIGPPL
PLKMVEEPVN PMEEGVLGPL PPPLAEDVEE EDDDDGDSEE EENPVRKIPD SHEITIKHGT
KTVSALGLDP SGARLVTGGY DYDVKFWDFA GMDASFKAFR SLQPCECHQI KSLQYSNTGD
MILVVSGSSQ AKVIDRDGFE VMECIKGDQY IVDMANTKGH TAMLHTGSWH PKIKGEFMTC
SNDATVRTWE VENPKKQKSV FKPRTMQGKK VIPTTCTYSR DGSLIAAACQ NGSIQIWDRN
LTVHPKFHYK QAHDPGTDTS CVTFSYDGTV LASRGGDDTL KLWDIRQFNK PLFSASGLPT
MFPMTDCCFS PDDKLIVTGT SVQRGCGSGK LVFFERRTFQ RVYEIDITDA SVVRCLWHPK
LNQIMVGTGN GLAKVYYDPN KSQRGAKLCV VKTQRKAKQA ETLTQDYIIT PHALPMFREP
RQRSTRKQLE KDRLDPLKSH KPEPPVAGPG RGGRVGTHGG TLSSYIVKNI ALDKTDDSNP
REAILRHAKA AEDNPYWVSP AYSKTQPKTM FAQVESDDEE TKNEPEWKKR KI
//
