ID EHF_BOVIN Reviewed; 300 AA.
AC Q32LN0;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 24-JAN-2024, entry version 133.
DE RecName: Full=ETS homologous factor;
DE AltName: Full=ETS domain-containing transcription factor;
GN Name=EHF;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional activator that may play a role in regulating
CC epithelial cell differentiation and proliferation. May act as a
CC repressor for a specific subset of ETS/AP-1-responsive genes, and as a
CC modulator of the nuclear response to mitogen-activated protein kinase
CC signaling cascades. Binds to DNA sequences containing the consensus
CC nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5
CC expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC -!- DOMAIN: The PNT domain acts as a transcriptional activator.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; BC109503; AAI09504.1; -; mRNA.
DR RefSeq; NP_001033125.1; NM_001038036.2.
DR RefSeq; XP_005216430.1; XM_005216373.3.
DR AlphaFoldDB; Q32LN0; -.
DR SMR; Q32LN0; -.
DR STRING; 9913.ENSBTAP00000068443; -.
DR PaxDb; 9913-ENSBTAP00000022792; -.
DR Ensembl; ENSBTAT00000022792.4; ENSBTAP00000022792.3; ENSBTAG00000017150.6.
DR GeneID; 505422; -.
DR KEGG; bta:505422; -.
DR CTD; 26298; -.
DR VEuPathDB; HostDB:ENSBTAG00000017150; -.
DR VGNC; VGNC:28375; EHF.
DR eggNOG; KOG3804; Eukaryota.
DR GeneTree; ENSGT00940000159310; -.
DR HOGENOM; CLU_048172_0_0_1; -.
DR InParanoid; Q32LN0; -.
DR OMA; CGSEMYP; -.
DR TreeFam; TF318679; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000017150; Expressed in prostate gland and 76 other cell types or tissues.
DR ExpressionAtlas; Q32LN0; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF171; ETS HOMOLOGOUS FACTOR; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..300
FT /note="ETS homologous factor"
FT /id="PRO_0000287132"
FT DOMAIN 29..115
FT /note="PNT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT DNA_BIND 207..289
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 179..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 35004 MW; F20E8A1F0184DB86 CRC64;
MILEGSGVMN LNPSNNLLHQ QPTWTDSYST CNVSSGFFGG QWHEIHPQYW TKYQVWEWLQ
HLLDTNQLDA SCIPFQEFDV NGEHLCSMSL QEFTRAAGTA GQLLYSNLQH LKWNGQCSSD
LFQSTHNVIV KTEQTDPSIM NTWKEENYLY DTNYGSTVDL LDSKTFCRAQ ISMTTTGHLP
IAESPDTKKE QDHPTKPHTK KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGIFRFL
KSEAVAQLWG KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN
//
