ID Q384G8_TRYB2 Unreviewed; 572 AA.
AC Q384G8;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
GN ORFNames=Tb11.01.0020 {ECO:0000313|EMBL:EAN79813.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN79813.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN79813.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN79813.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH464491; EAN79813.1; -; Genomic_DNA.
DR RefSeq; XP_828925.1; XM_823832.1.
DR AlphaFoldDB; Q384G8; -.
DR STRING; 185431.Q384G8; -.
DR PaxDb; 5691-EAN79813; -.
DR GeneID; 3665081; -.
DR KEGG; tbr:Tb11.01.0020; -.
DR eggNOG; KOG2094; Eukaryota.
DR InParanoid; Q384G8; -.
DR OrthoDB; 146204at2759; -.
DR Proteomes; UP000008524; Chromosome 11 Scaffold 1.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EAN79813.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Transferase {ECO:0000313|EMBL:EAN79813.1}.
FT DOMAIN 135..318
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT COILED 75..132
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 572 AA; 63519 MW; D7145A9EFD818963 CRC64;
MCGGEENGGL DQAHVSYSGS ASEQNIAEMI VDPSASRQPT AFQLTLDCNK AGMGNVDKER
VEAIIRGAGE GTPFLLNEQR LVEGREKQLR ELKRKSSLFT RLLGGERNAA QRTQWEVKVS
KIEQELEATR RLGTYIHLDM DMFYAAVEIK KHPEYATIPL AIGTMTRLQT ANYIARGRGI
RQGMPGFLAL KICPNLLILP PDDDSYNEES NTVRRIVAEY DPNYIVVGLD ELALEVSAYI
ERFEGTKTAE DVASELRVRV FGETKLTASA GIGPTAALAK IASNINKPNG QHDLNLHTRE
DVMTYVRDLG LRSVPGVGKV TEALLKGLGI TTLSDIYNRR VELCYILHNN LFRFLLGASI
GIMQWPDAAT AANTENCEGA TGEQRKAISS ERSITTPRTK EGMQEMVDTV FNGAYEEMRK
SEIMCRRISL TIRWASYRYQ QYTKSLIQHS DDSATLRRAV DELMLPHAAK YSEMCLLGVR
LSDLISAKDF HMKRKGGNQL SISQFIRPKK PGEVTATTGI KRERTTEPKQ VVEIIISSDD
EDENDSVGLA SSSTILVSTD KGTVEREVTI IE
//
