ID Q385P9_TRYB2 Unreviewed; 1498 AA.
AC Q385P9;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=U2A'/phosphoprotein 32 family A C-terminal domain-containing protein {ECO:0000259|SMART:SM00446};
GN ORFNames=Tb11.02.2850 {ECO:0000313|EMBL:EAN79482.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN79482.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN79482.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN79482.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
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DR EMBL; CH464491; EAN79482.1; -; Genomic_DNA.
DR RefSeq; XP_828594.1; XM_823501.1.
DR AlphaFoldDB; Q385P9; -.
DR STRING; 185431.Q385P9; -.
DR PaxDb; 5691-EAN79482; -.
DR GeneID; 3664824; -.
DR KEGG; tbr:Tb11.02.2850; -.
DR VEuPathDB; TriTrypDB:Tb927.11.5190; -.
DR eggNOG; KOG0531; Eukaryota.
DR InParanoid; Q385P9; -.
DR OrthoDB; 1379687at2759; -.
DR Proteomes; UP000008524; Chromosome 11 Scaffold 1.
DR GO; GO:0005929; C:cilium; IDA:GeneDB.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 7.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46652:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1; 1.
DR Pfam; PF12799; LRR_4; 2.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SMART; SM00365; LRR_SD22; 12.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00446; LRRcap; 3.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR PROSITE; PS51450; LRR; 10.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 243..261
FT /note="U2A'/phosphoprotein 32 family A C-terminal"
FT /evidence="ECO:0000259|SMART:SM00446"
FT DOMAIN 1127..1145
FT /note="U2A'/phosphoprotein 32 family A C-terminal"
FT /evidence="ECO:0000259|SMART:SM00446"
FT DOMAIN 1383..1401
FT /note="U2A'/phosphoprotein 32 family A C-terminal"
FT /evidence="ECO:0000259|SMART:SM00446"
FT REGION 1466..1498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1498 AA; 168287 MW; D289AD71B7F777F2 CRC64;
MVYESESCRN ITSAEDRGRA SSVVVEHLRA AIVQAMKSSE TAELVALICD NNGLTVEEFL
QAPHEFTEME LFLLATPQLP QLRLFPYLTV VKVMHVGLES MEPFSPLHHI EELWLCDNNI
TVIEGVRQMR SLKYLYLQGN LIESMDGIPS LPNLERLWLC RNRLQNIRKL DLLPQLRSLW
VASNRITSLE GAFDSSMTAL EELNLSNNQI YFFGQIKNLS VLKSLRVLWL SDPMYGDAPI
YHLSNYTTFS LQHLPHLEQL DGVSITMEQR SLTVSVYAKK SIYYSMRGAI LNGNVALMYK
FAQQEAEKKR NFARDAIRRL DIQLMKLGEY GRDGQYVSRV VTAEEEAHRQ TLKRARETRE
VELEGIERQL LEAWSRTTFE TESLHERLLL ELNSCGSIRL EEGSEADSWY VNAGELLTSR
FDADLYEGMG VTGVKVNRVF RITCQGLRER FDNRIRELDV DLADTRNRRA LIRLFSAIPR
HAKDQRSFLY EVMTNGFPGL YAEDEGVPLT NSLFYADQER LLSLKRNRNI FGLTSQPDQL
SAQLLVSRLF LGKCVAEMGG GRDTSLEEGG DKAVEQPFMT GRRKVTRRHY GDGVFSVYRA
SEHNPAVKVW HVFDKCLLLP EYVIDFTYTT KAHLTISPPL SMYDKRESLQ ALLDKVMPMG
AQDAINDART AGYPLLHFLH WLDSNAFHVY SSGETEKAIS RAKELYQPKH GLMLINGPLT
NELVDSYISN YGTLSDSMLT YCDISEKQIH CIPESLTTSA WGALKTLLLH HNKITTVAWE
ALANAAPTLE TLDLGNNEIA RIDLGAASFP GLKKLCLSFN SCSAMDDLRQ LPAKMPELCC
LHIDHNPWMM NKVVEPFCVS IMPELQQLNG IAISRHARLS YLRKRTLMLN QSTLQYIVSE
EQKLRAESAT EAFPNSGCGN VLDDSSSSNN NNSDVFRSRY FEQVIANMAD RVNQDRPFAP
TAGKELSGPP LRSVRAFSFH SSLSSDIKWV TLLPQLRHLS LTSHLIEDIS PLAQLRHLRT
LNLNDNLVNS TKPLEGMRLI SLDLSRNCLY EVDGIASLCD LRFLSIRQNF ITSVTELQNC
LSLEELYLAD NNVPDVRELC LLQSLPKLVS MDAAGNLCAE RENAEKLTEY RDCLLYNMPK
LKVLDGLPVA EADQQRARDV FAGRVSADLL IERVGPVEMW GTAQEVDLSH CGLRELTLLD
PFSCLRVLHL HHNNLERIDG LSSLTSIVAL DLSHNRLGHC AVGRVLRNLP NIHSLSLEGN
HITDVSALSL ALPRLQFLNL KGNEISSIET GLQDLPALRE LLLDNNKLRA LGPDCFANNH
QLTDVSADEN YIRTIDGLQS LPRLSILSLG SNRLGDIRAI AQVLRHSGCL AAATFIGNAV
ARKPPYRVHM IAALPTLTTL DHREITDDER ERAELMRNAE IGTPHNVVLD TTFPAEAVGG
ARASAPVGTL RSIVLHSHRF PAPATPRLQL PVCKNPRGEQ HGREGVGKGF APRLHGAR
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