ID Q389H3_TRYB2 Unreviewed; 941 AA.
AC Q389H3;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=Tb10.26.0220 {ECO:0000313|EMBL:EAN78547.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN78547.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN78547.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN78547.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; CM000208; EAN78547.1; -; Genomic_DNA.
DR RefSeq; XP_823375.1; XM_818282.1.
DR AlphaFoldDB; Q389H3; -.
DR STRING; 185431.Q389H3; -.
DR PaxDb; 5691-EAN78547; -.
DR GeneID; 3662808; -.
DR KEGG; tbr:Tb10.26.0220; -.
DR eggNOG; KOG0474; Eukaryota.
DR InParanoid; Q389H3; -.
DR OMA; HEPRWFM; -.
DR OrthoDB; 125473at2759; -.
DR Proteomes; UP000008524; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:GeneDB.
DR GO; GO:0005768; C:endosome; IDA:GeneDB.
DR GO; GO:0005576; C:extracellular region; ISM:GeneDB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISM:GeneDB.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; ISM:GeneDB.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; ISM:GeneDB.
DR GO; GO:0006821; P:chloride transport; ISM:GeneDB.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd01036; ClC_euk; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689:SF68; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 65..92
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 150..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 197..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 261..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 296..322
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 334..352
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 358..386
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 544..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 573..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 607..633
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 791..855
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 858..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 104107 MW; D094B8150AB57070 CRC64;
MPLLEERHDL SLRQKLQATI PTRHPRFYSS EERRKMERYE SVDTFEPATT VYKDHLAGRS
QEPRWFIWVF VVVIGIAVSF TAIVVVALLH VFASVRYELL GYGLNNFSFY NPNRYPERSP
DHAELDFTAM FEGVGVGLYG ISPRSYMKGY LMWVSFSFVT SLISSVICIC VPGSVGAGMP
EVMAYLNGVD YPMLGSFGVL LAKIASVVFS VASGVCTGHC GTLMLTGAMV GAQTLQRRRW
IQIEHVNIIE CFRNPRDRRT IVVIGAAAGI ASAFNVSIGG LMVVVELIST TIPVRFALYV
FAASLVSSLF IQVYFSHFLY FAGRDRTGYS SGELISELVQ VFASTIPFEQ IVRMHILYFI
PTVVIGFICG ALSGVYVRLS WFALVVRRHL EQRFKVRAFR ALLPVAFTVA YVSLHYWMVV
AFGSAGWSPP SSALNPTDNT TAGGLTTLRW GNSSAVSPHF VDTQSGPCVA VPQTLSDSRD
VSVISFYGAN GFFCAAPNNT VIPVTATVHE QQVWIVLHSY ASLAFANADS ALQTLLSLRT
ETMLSLPVLM IFLLIYYTSS AIFLGISPCG DTVFPTLVVG ATVGRIVGLV VFLIVSPGSR
SSWADPGIFA LIGAGSFVGG TTGLAFSICT ILMESTGQFQ HMLPLMVGIM IAKKTAEIFT
HNINAVLLEA RCVPMLNYMN VVEKYPMFDA RHVMSSKVVV LETVTPIGRV VDVLENTRHN
AFPIESVRDQ TYKGVVMRRQ LEIVLWHLYY SHHLSTCSYE CGKRVEASLY RDNLHGVLPP
LEKWLDAQLD LSPYIDYSGF CVLATATLPR TYQMFLTLGL RHLTVVDSGN RIVGIITRKD
LMADRIIESI IRTDRRRRRI QGSRKHSTNT GSSDVADVEV AGGEESSEVA SGRSASGWEA
ALKYEFYRSG EWCVSDEEDR VSENNSIREE PGGTWKPDAT F
//
