ID Q389T6_TRYB2 Unreviewed; 711 AA.
AC Q389T6;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 24-JAN-2024, entry version 110.
DE SubName: Full=Minichromosome maintenance (MCM) complex subunit, putative {ECO:0000313|EMBL:EAN78434.1};
GN ORFNames=Tb10.406.0500 {ECO:0000313|EMBL:EAN78434.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN78434.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN78434.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN78434.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000208; EAN78434.1; -; Genomic_DNA.
DR RefSeq; XP_823262.1; XM_818169.1.
DR AlphaFoldDB; Q389T6; -.
DR STRING; 185431.Q389T6; -.
DR PaxDb; 5691-EAN78434; -.
DR GeneID; 3662515; -.
DR KEGG; tbr:Tb10.406.0500; -.
DR VEuPathDB; TriTrypDB:Tb927.10.10410; -.
DR eggNOG; KOG0480; Eukaryota.
DR InParanoid; Q389T6; -.
DR OMA; RFDIIAC; -.
DR OrthoDB; 179306at2759; -.
DR Proteomes; UP000008524; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0042555; C:MCM complex; IDA:GeneDB.
DR GO; GO:0005654; C:nucleoplasm; IDA:GeneDB.
DR GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; ISM:GeneDB.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; ISA:GeneDB.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 318..518
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 711 AA; 77531 MW; EF8372438ED96241 CRC64;
MSMNGVPQEA VKVLWAVHCS HLAPLSYDED AVGEMWRLFA GFLAPLQIRS SSASKEHMPC
LKLAIFTFTV DLRIDMMETP MRNAVVGQPR LVIPLLEFFK AVLYFQQHQK NRQIGELGSW
RLLCIVIGDD GCATPFDTLG ASLLGKLVTV RGTVVRMSPP RVTCVEMTYR CNLCAAVVKA
PTEDGVLVYP GRCSGRCRGY NWAPLLERGE CEEVQLLKVQ EQTESYDGST VGSGIHNMIV
VDLRGIWINI ATVGEHVVVC GVLCARRGEG RTNATQQIAV RACFVENSRH SAVRGPMQTI
DSLEESGRFY EMVRNPQWFS MLCGSLAPSI FGLEHVKEAI ILAVVGGTAM KKRTRSNIHL
LIVGDPGLGK SQLLRAACTV APRSSFVCAH TSSSCGLTLT LSRDPTTGET SFEAGAVVHG
DGGITCIDEI DKGVPEHNAL LEVMEQESVS MAKAGMVFSV PVHTAILTAG NPIGGRFDDT
KSIPANLNLS PALFTRFDIV ICMRSPSADA SRSLSDHVLQ LHRCVKGGGS RTVAKTSGPP
LPLETVQRFI AFCRHNCHPS LRQEACDVLK AYYLQRRAEA AMGELAVTPR FLQALIRVSE
ARAKVELRHE VTAEDARYAV ELMKRCFGSH NFGRRQPTCT GAAAKKMTQR EKILDALKGE
VCRTGVNALS HRTVLAACEE AGCRDANAMV YQLNEAGVIL QMGGKYQLRG V
//
