ID Q38AD5_TRYB2 Unreviewed; 740 AA.
AC Q38AD5;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Eukaryotic translation initiation factor 3 subunit 8, putative {ECO:0000313|EMBL:EAN78235.1};
GN ORFNames=Tb10.6k15.2220 {ECO:0000313|EMBL:EAN78235.1}, Tb10.6k15.2250
GN {ECO:0000313|EMBL:EAN78233.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN78235.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN78235.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [2] {ECO:0000313|EMBL:EAN78235.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN78235.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
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DR EMBL; CM000208; EAN78233.1; -; Genomic_DNA.
DR EMBL; CM000208; EAN78235.1; -; Genomic_DNA.
DR RefSeq; XP_823061.1; XM_817968.1.
DR RefSeq; XP_823063.1; XM_817970.1.
DR AlphaFoldDB; Q38AD5; -.
DR STRING; 185431.Q38AD5; -.
DR PaxDb; 5691-EAN78233; -.
DR GeneID; 3662211; -.
DR GeneID; 3663045; -.
DR KEGG; tbr:Tb10.6k15.2220; -.
DR KEGG; tbr:Tb10.6k15.2250; -.
DR VEuPathDB; TriTrypDB:Tb927.10.8270; -.
DR VEuPathDB; TriTrypDB:Tb927.10.8290; -.
DR eggNOG; KOG1076; Eukaryota.
DR InParanoid; Q38AD5; -.
DR OMA; ETNERAM; -.
DR OrthoDB; 149872at2759; -.
DR Proteomes; UP000008524; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISO:GeneDB.
DR GO; GO:0003729; F:mRNA binding; IDA:GeneDB.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; ISM:GeneDB.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR PANTHER; PTHR13937; EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED; 1.
DR PANTHER; PTHR13937:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED; 1.
DR Pfam; PF05470; eIF-3c_N; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EAN78235.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 169..511
FT /note="Eukaryotic translation initiation factor 3 subunit C
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF05470"
FT REGION 720..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 84340 MW; 87F31284D32F1FB0 CRC64;
MADFFNVSDS DESIDEVIQR DDQVERNTAQ IDPKWFEITD DEAAEEQRVV LSRREKSLNE
IQTNADVFDF NVDQGTWVGA EQSFKELREK SDIHKRRFQS TPFPFLECLR NTPDLKTHLS
ERESFAKPEE FRSLKGLIKA VEEAMETYKD DIERLYDEED GDEGDEEEAE KELTEDDIVK
QLRESVTCTG KKASKYRKLA NECKRKGYKA LQITTCGIVA DALLEEDNRE VYVSTKTWAK
SCDTLEECFG LIVENPGIRL SDKFSDKLNK RDAFIKGGLH ALLQSLSKHL RRITQFKDGI
PSDYIEIVHL ENRLVAIADA LFGYYRDNSR GRAVCCQILV DILGSRRQEA HEILFGKMPP
GQREAVSDSV IETVRSLYEQ LLLIGDDESK SLALLHLVYQ MGLEGKYREG RDLIRRSGGA
EKLCNSNHNS VLYNRAVAQL GLASFIMGDI MQAYELLSPL WNSWEGPEVL IGQKLPNLKD
EKGDEELRYR DLLLPPHAHI PYSQLELATM LSTLVVGTVD EAKKPYEVTH HHRYFYRVIN
QMQFQPLLGE PIEFREQITA AYTALKLGDY ARSSEVIKNM KVWDNMPRGT EARDTFLQRL
KEAALQIFCY NSRRSFATIS VEIMAKKFDI TESTVKHVIN GIISENNTPL IAVWDRDDQY
LHVDRSNISR LQYLVEATAR SVENIAHYCE KGGHGNDFRG GRGQGYMRGG RGFGRGGGSD
FRGAADYGRG RGRGRARGGQ
//
