ID Q38AE1_TRYB2 Unreviewed; 497 AA.
AC Q38AE1;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Protein disulfide isomerase {ECO:0000313|EMBL:EAN78229.1};
DE EC=5.3.4.1 {ECO:0000313|EMBL:EAN78229.1};
GN ORFNames=Tb10.6k15.2290 {ECO:0000313|EMBL:EAN78229.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN78229.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN78229.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN78229.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC {ECO:0000256|ARBA:ARBA00006347, ECO:0000256|RuleBase:RU004208}.
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DR EMBL; CM000208; EAN78229.1; -; Genomic_DNA.
DR RefSeq; XP_823057.1; XM_817964.1.
DR AlphaFoldDB; Q38AE1; -.
DR SMR; Q38AE1; -.
DR STRING; 185431.Q38AE1; -.
DR PaxDb; 5691-EAN78229; -.
DR GeneID; 3663041; -.
DR KEGG; tbr:Tb10.6k15.2290; -.
DR VEuPathDB; TriTrypDB:Tb927.10.8230; -.
DR eggNOG; KOG0190; Eukaryota.
DR InParanoid; Q38AE1; -.
DR OMA; FRSKHEP; -.
DR OrthoDB; 5399045at2759; -.
DR Proteomes; UP000008524; Chromosome 10.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR CDD; cd02961; PDI_a_family; 1.
DR CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR CDD; cd02982; PDI_b'_family; 1.
DR CDD; cd02981; PDI_b_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 4.
DR InterPro; IPR005788; PDI_thioredoxin-like_dom.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR NCBIfam; TIGR01126; pdi_dom; 1.
DR PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR PANTHER; PTHR18929:SF246; PROTEIN DISULFIDE-ISOMERASE; 1.
DR Pfam; PF00085; Thioredoxin; 2.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 4.
DR PROSITE; PS00194; THIOREDOXIN_1; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 2.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EAN78229.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..497
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004221835"
FT DOMAIN 8..124
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DOMAIN 334..455
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 461..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 55580 MW; 3BEAA2AF9FA6C76D CRC64;
MRAIFLVALA LATMRESTAE SLKLTKENFN ETIAKSEIFL VKFYVDTCGY CQMLAPEWEK
AANETIDNAL MGEVDCHSQP ELAANFSIRG YPTIILFRNG KEAEHYGGAR TKDDIIKYIK
ANVGPAVTPA SNAEEVTRAK EEHDVVCVGL TASNSTSLST TLAEAAQSFR VSLKFFEAEP
KLFPDEKPET IVVYRKGGEK EVYDGPMEVE KLTEFLQISR VAFGGEITPE NYQYYSVIKR
PVGWAMVKPN ETASIELKES LTEVGKKMRS HMVVLWVNIS KHPVWRDFGV PEDAKYPAFL
AIHWGANYLH STAEVVTRES LEKFILEFAA GRVEPTIKSL PVPEVETVDG KTTIVAKTMQ
KHLTSGKDML ILFFAPWCGH CKNFAPTFDK IAKEFDATDL IVAELDATAN YVNSSTFTVT
AFPTVFFVPN GGKPVVFEGE RSFENVYEFV RKHVTTFKVS EKPANVTEEK KSEEENKSSR
SNESNDSNES NVDKQDL
//
