ID Q38DZ5_TRYB2 Unreviewed; 356 AA.
AC Q38DZ5;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=phosphatidylserine decarboxylase {ECO:0000256|ARBA:ARBA00012243};
DE EC=4.1.1.65 {ECO:0000256|ARBA:ARBA00012243};
GN ORFNames=Tb09.211.1610 {ECO:0000313|EMBL:EAN76975.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN76975.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN76975.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN76975.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- COFACTOR:
CC Name=pyruvate; Xref=ChEBI:CHEBI:15361;
CC Evidence={ECO:0000256|ARBA:ARBA00001928};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis. {ECO:0000256|ARBA:ARBA00024326}.
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DR EMBL; CM000207; EAN76975.1; -; Genomic_DNA.
DR RefSeq; XP_827305.1; XM_822212.1.
DR AlphaFoldDB; Q38DZ5; -.
DR STRING; 185431.Q38DZ5; -.
DR PaxDb; 5691-EAN76975; -.
DR GeneID; 3660694; -.
DR KEGG; tbr:Tb09.211.1610; -.
DR VEuPathDB; TriTrypDB:Tb927.9.10080; -.
DR eggNOG; KOG2420; Eukaryota.
DR InParanoid; Q38DZ5; -.
DR OMA; KDYHHYH; -.
DR OrthoDB; 141389at2759; -.
DR BRENDA; 4.1.1.65; 6519.
DR UniPathway; UPA00558; -.
DR Proteomes; UP000008524; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004609; F:phosphatidylserine decarboxylase activity; EXP:GeneDB.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR GO; GO:0006660; P:phosphatidylserine catabolic process; EXP:GeneDB.
DR InterPro; IPR003817; PS_Dcarbxylase.
DR InterPro; IPR033177; PSD-B.
DR NCBIfam; TIGR00163; PS_decarb; 1.
DR PANTHER; PTHR10067; PHOSPHATIDYLSERINE DECARBOXYLASE; 1.
DR PANTHER; PTHR10067:SF6; PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL; 1.
DR Pfam; PF02666; PS_Dcarbxylase; 1.
PE 4: Predicted;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 356 AA; 39736 MW; 7E400B6D5F0F463B CRC64;
MASLTRQLRF YKNDTTRPFT NPMRRWLYHY LFGGAIIGGA VYVGGRYQLA AWEATRHPEG
GTRLCSVGML EMLMLFPFNY ISHICGRISE NECLPSSFHR AVIAAIIWWY GMDAPRGKER
EYKTLQEFFV RRWEDGERRV ATSPVVMPSD GVVLSVQEDV VDDQLLQVKG VTYSVRRLFH
SPLGTVAEGN RRIAVALHLR TQDYHHVVTP CLFTCKEVVY IPGALLPHTP AGYHWIPSVL
PLNERVVLLG SWTDEHSASG NMGLALVGGT LTGRIVLHLD QRIKTNFLAP PEYAVHRCYS
RAATSKKGDL LSTFYWGSSV VLVLDIPKTA SVAVKPGDIV KAGEALVTYG LSESGK
//
