ID IDI1_CLABR Reviewed; 287 AA.
AC Q39472;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 13-SEP-2023, entry version 95.
DE RecName: Full=Isopentenyl-diphosphate Delta-isomerase I;
DE EC=5.3.3.2;
DE AltName: Full=Isopentenyl pyrophosphate isomerase I;
DE Short=IPP isomerase I;
GN Name=IPI1;
OS Clarkia breweri (Fairy fans) (Eucharidium breweri).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Onagraceae; Onagroideae; Onagreae; Clarkia.
OX NCBI_TaxID=36903;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7610186; DOI=10.1104/pp.108.2.855;
RA Blanc V.M., Pichersky E.;
RT "Nucleotide sequence of a Clarkia breweri cDNA clone of Ipi1, a gene
RT encoding isopentenyl pyrophosphate isomerase.";
RL Plant Physiol. 108:855-856(1995).
CC -!- FUNCTION: Catalyzes the 1,3-allylic rearrangement of the homoallylic
CC substrate isopentenyl (IPP) to its highly electrophilic allylic isomer,
CC dimethylallyl diphosphate (DMAPP). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=isopentenyl diphosphate = dimethylallyl diphosphate;
CC Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769;
CC EC=5.3.3.2;
CC -!- PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate
CC biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate:
CC step 1/1.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC biosynthesis.
CC -!- SIMILARITY: Belongs to the IPP isomerase type 1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA57947.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X82627; CAA57947.1; ALT_INIT; mRNA.
DR PIR; S49588; S49588.
DR AlphaFoldDB; Q39472; -.
DR SMR; Q39472; -.
DR UniPathway; UPA00059; UER00104.
DR UniPathway; UPA00668; -.
DR GO; GO:0004452; F:isopentenyl-diphosphate delta-isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR CDD; cd02885; IPP_Isomerase; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR011876; IsopentenylPP_isomerase_typ1.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR NCBIfam; TIGR02150; IPP_isom_1; 1.
DR PANTHER; PTHR10885; ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE; 1.
DR PANTHER; PTHR10885:SF0; ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
PE 2: Evidence at transcript level;
KW Chlorophyll biosynthesis; Isomerase; Isoprene biosynthesis; Photosynthesis.
FT CHAIN 1..287
FT /note="Isopentenyl-diphosphate Delta-isomerase I"
FT /id="PRO_0000205236"
FT DOMAIN 105..257
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT ACT_SITE 142
FT /evidence="ECO:0000250"
FT ACT_SITE 207
FT /evidence="ECO:0000250"
SQ SEQUENCE 287 AA; 32956 MW; 204E729D07382AA7 CRC64;
MSSSMLNFTA SRIVSLPLLS SPPSRVHLPL CFFSPISLTQ RFSAKLTFSS QATTMGEVVD
AGMDAVQRRL MFEDECILVD ENDKVVGHES KYNCHLMEKI ESENLLHRAF SVFLFNSKYE
LLLQQRSATK VTFPLVWTNT CCSHPLYRES ELIDENCLGV RNAAQRKLLD ELGIPAEDLP
VDQFIPLSRI LYKAPSDGKW GEHELDYLLF IIRDVNLDPN PDEVAEVKYM NRDDLKELLR
KADAEEEGVK LSPWFRLVVD NFLFKWWDHV EKGSLKDAAD MKTIHKL
//
