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Database: UniProt
Entry: Q3E7X8
LinkDB: Q3E7X8
Original site: Q3E7X8 
ID   YE077_YEAST             Reviewed;        1277 AA.
AC   Q3E7X8; D3DLH4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   18-SEP-2019, entry version 106.
DE   RecName: Full=Y' element ATP-dependent helicase YEL077C;
DE            EC=3.6.4.12;
GN   OrderedLocusNames=YEL077C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G.,
RA   Hunicke-Smith S., Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H.,
RA   Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P.,
RA   Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T.,
RA   Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
RA   Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and
RT   now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=9837911; DOI=10.1074/jbc.273.50.33360;
RA   Yamada M., Hayatsu N., Matsuura A., Ishikawa F.;
RT   "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y'
RT   element, is induced in survivors defective for telomerase.";
RL   J. Biol. Chem. 273:33360-33366(1998).
CC   -!- FUNCTION: Catalyzes DNA unwinding and is involved in telomerase-
CC       independent telomere maintenance. {ECO:0000269|PubMed:9837911}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- INDUCTION: Induced in absence of telomerase TLC1.
CC       {ECO:0000269|PubMed:9837911}.
CC   -!- SIMILARITY: Belongs to the helicase family. Yeast subtelomeric Y'
CC       repeat subfamily. {ECO:0000305}.
DR   EMBL; U73806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006939; DAA07578.1; -; Genomic_DNA.
DR   RefSeq; NP_010835.1; NM_001184302.1.
DR   BioGrid; 36654; 24.
DR   DIP; DIP-48278N; -.
DR   STRING; 4932.YEL077C; -.
DR   CarbonylDB; Q3E7X8; -.
DR   PaxDb; Q3E7X8; -.
DR   PRIDE; Q3E7X8; -.
DR   EnsemblFungi; YEL077C_mRNA; YEL077C; YEL077C.
DR   GeneID; 856630; -.
DR   KEGG; sce:YEL077C; -.
DR   EuPathDB; FungiDB:YEL077C; -.
DR   SGD; S000006409; YEL077C.
DR   HOGENOM; HOG000155528; -.
DR   BioCyc; YEAST:G3O-30356-MONOMER; -.
DR   PRO; PR:Q3E7X8; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004386; F:helicase activity; ISS:SGD.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN         1   1277       Y' element ATP-dependent helicase
FT                                YEL077C.
FT                                /FTId=PRO_0000268166.
FT   DOMAIN      222    399       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      454    605       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     235    242       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       345    348       DEAH box.
FT   COMPBIAS    683    875       Thr-rich.
SQ   SEQUENCE   1277 AA;  143092 MW;  430F1585F29AFD27 CRC64;
     MTLGNSYDAF NHDPWMDVVG FEDPNQVTNR DISRIVLYSY MFLNTAKGCL VEYATFRQYM
     RELPKNAPQK LNFREMRQGL IALGRHCVGS RFETDLYESA TSELMANHSV QTGRNIYGVD
     SFSLTSVSGT TATLLQERAS ERWIQWLGLE SDYHCSFSST RNAEDVVAGE AASSDHHQKI
     SRVTRKRPRE PKSTNDILVA GQKLFGSSFE FRDLHQLRLC YEIYMADTPS VAVQAPPGYG
     KTELFHLPLI ALASKGDVKY VSFLFVPYTV LLANCMIRLG RCGCLNVAPV RNFIEEGYDG
     VTDLYVGIYD DLASTNFTDR IAAWENIVEC TFRTNNVKLG YLIVDEFHNF ETEVYRQSQF
     GGITNLDFDA FEKAIFLSGT APEAVADAAL QRIGLTGLAK KSMDINELKR SEDLSRGLSS
     YPTRMFNLIK EKSEVPLGHV HKIRKKVESQ PEEALKLLLA LFESEPESKA IVVASTTNEV
     EELACSWRKY FRVVWIHGKL DAAEKVSRTK EFVTDGNMRV LIGTKLVTEG IDIKQLMMVI
     MLDNRLNIIE LIQGVGRLRD GGLCYLLSRK NSWAARNRKG ELPPIKEGCI TEQVREFYGL
     ESKKGKKGQH VGCCGSRTDL SADTVELIER MDRLAEKQAT ASMSIVALPS NFQESNSSDR
     YRKYCSSDED SNTCIHGSAN ASTNASTNAI TTASTNVRTN ATTNASTNAT TNASTNATTN
     SSTNATTTAS TNVRTSATTT ASINVRTSAT TTESTNSSTN ATTTASINVR TSATTTKSIN
     SSTNATITES TNSNTNATTT ESTNSKTSAT TTASTNSNTS ATTTESTNSK TSATTTASTN
     SNTSATTTES TNSNTSATTT ASTNSSTNAT TTESTNASAK EDANKDGNAE DNRFHPVTDI
     NKESYKRKGS QMVLLERKKL KAQFPNTSEN MNVLQFLGFR SDEIKHLFLY GIDIYFCPEG
     VFTQYGLCKG CQKMFELCVC WAGQKVSYRR MAWEALAVER MLRNDEEYKE YLEDIEPYHG
     DPVGYLKYFS VKRREIYSQI QRNYAWYLAI TRRRETISVL DSTRGKQGSQ VFRMSGRQIK
     ELYYKVWSNL RESKTEVLQY FLNWDEKKCQ EEWEAKDDTV FVEALEKVGV FQRLRSMTSA
     GLQGPQYVKL QFSRHHRQLR SRYELSLGMH LRDQIALGVT PSKVPHWTAF LSMLIGLFYN
     KTFRQKLEYL LEQISEVWLL PHWLDLANVE VLAADNTKVP LYMLMVAVHK ELDSDDVPDG
     RFDIILLCRD SSREVGE
//
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