ID Q3HWG4_ONCMY Unreviewed; 199 AA.
AC Q3HWG4; A0A8C7RAS1;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 06-DEC-2005, sequence version 2.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Insulin-like growth factor binding protein 6 {ECO:0000313|EMBL:ABA55019.2, ECO:0000313|Ensembl:ENSOMYP00000049448.2};
GN Name=IGFBP6 {ECO:0000313|EMBL:ABA55019.2};
GN Synonyms=igfbp6 {ECO:0000313|Ensembl:ENSOMYP00000049448.2};
GN ORFNames=GSONMT00013525001 {ECO:0000313|EMBL:CDQ96902.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:ABA55019.2};
RN [1] {ECO:0000313|EMBL:ABA55019.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16439447; DOI=10.1210/en.2005-1570;
RA Kamangar B.B., Gabillard J.C., Bobe J.;
RT "Insulin-like growth factor-binding protein (IGFBP)-1, -2, -3, -4, -5, and
RT -6 and IGFBP-related protein 1 during rainbow trout postvitellogenesis and
RT oocyte maturation: molecular characterization, expression profiles, and
RT hormonal regulation.";
RL Endocrinology 147:2399-2410(2006).
RN [2] {ECO:0000313|EMBL:CDQ96902.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [3] {ECO:0000313|EMBL:CDQ96902.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ABA55019.2}
RP NUCLEOTIDE SEQUENCE.
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSOMYP00000049448.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; DQ190459; ABA55019.2; -; mRNA.
DR EMBL; FR927852; CDQ96902.1; -; Genomic_DNA.
DR RefSeq; NP_001118032.1; NM_001124560.1.
DR STRING; 8022.Q3HWG4; -.
DR PaxDb; 8022-Q3HWG4; -.
DR Ensembl; ENSOMYT00000053748.2; ENSOMYP00000049448.2; ENSOMYG00000022473.2.
DR GeneID; 100136311; -.
DR KEGG; omy:100136311; -.
DR CTD; 3489; -.
DR GeneTree; ENSGT00940000160528; -.
DR OrthoDB; 5394492at2759; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR Proteomes; UP000694395; Chromosome 9.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR022326; IGFBP-6.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF14; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 6; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01982; IGFBPFAMILY6.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..199
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015097410"
FT DOMAIN 17..98
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 122..196
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 98..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 176..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 199 AA; 21478 MW; 2F6D442FA8F4F23E CRC64;
MPLLSNLTTI ILLLIAHCAS STLANRLGPY KGCFSCKEPG RAPRDHIGQA GSTSMLAQGE
PCGVYTMSCA KGLRCVPLPQ EHSPLQALLQ GRGICTKQSR TSPTERPHPT GPHPSHSGEI
EKAPCRKLLN SVLRGVELTI FLSDRDIYIP NCDTLGFYRK KQCRSSKGVQ RGLCWCVDEL
GTALSSRASE DGTLPCDGD
//
