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Database: UniProt
Entry: Q3ITS0
LinkDB: Q3ITS0
Original site: Q3ITS0 
ID   UVRB_NATPD              Reviewed;         683 AA.
AC   Q3ITS0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   31-JUL-2019, entry version 89.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204};
GN   OrderedLocusNames=NP_0744A;
OS   Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 /
OS   NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria;
OC   Halobacteriales; Haloarculaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 /
RC   Gabara;
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
DR   EMBL; CR936257; CAI48463.1; -; Genomic_DNA.
DR   RefSeq; WP_011322099.1; NC_007426.1.
DR   SMR; Q3ITS0; -.
DR   STRING; 348780.NP_0744A; -.
DR   GeneID; 3703458; -.
DR   KEGG; nph:NP_0744A; -.
DR   eggNOG; arCOG04748; Archaea.
DR   eggNOG; COG0556; LUCA.
DR   HOGENOM; HOG000073580; -.
DR   KO; K03702; -.
DR   OMA; RYMHSEI; -.
DR   OrthoDB; 4923at2157; -.
DR   BioCyc; NPHA348780:G1GI2-379-MONOMER; -.
DR   Proteomes; UP000002698; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR041471; UvrB_inter.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome;
KW   SOS response.
FT   CHAIN         1    683       UvrABC system protein B.
FT                                /FTId=PRO_0000227389.
FT   DOMAIN       39    417       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      442    604       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      630    665       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      52     59       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF       105    128       Beta-hairpin.
SQ   SEQUENCE   683 AA;  77602 MW;  DD7999D014477A14 CRC64;
     MTDTGPLQPD RPDLDRPLSV DAPFEPAGDQ PDAIETLVAG FESGAEKQTL LGVTGSGKTN
     TVSWVLEELQ QPTLVLAHNK TLAAQLYEEF RELFPDNAVE YFVSYYDYYQ PEAYVEQTDT
     YIDKDMSINE EIERLRHSAT RSLLTRDDVI VVASVSAIYG LGDPANYEEM ALRLEAGDER
     SREDLLSALV ELNYERNDVD FQQGTFRVRG DTVEIYPMYG RHAVRVEFWG DEIDRLLKVD
     IVDGEVVSEE PATLIHPAEH YSVPDRRLET AIEEIEGLLE DRIDYFERQG DLVAAQRIEE
     RTTFDIEMLQ ETGHCSGIEN YSVHMSDRET GEPPYTLLDY FPDGFLTVID ESHQTIPQIK
     GQFEGDRSRK ESLVENGFRL PTAYDNRPLK FEEFEAKTDR TLYVSATPGD YERDHSEQVV
     EQIVRPTYLV DPDIEVEPAE KQVEDLIERI QATPEDERVL VTTLTKRMAE DLTEYLENAG
     VDVAYMHDET DTLERHELVR SLRLGEIQVL VGINLLREGL DIPEVSLVAI LDADQEGFLR
     SETTLVQTMG RAARNVEGSV VLYADETTDS MAAAIEETRR RREIQREFNA EHGHEPRTIE
     KPVSETNLPG SSTDTDGVAD VAPDTVDEAE QLIERLETRM QEAADNLEFE LAADIRDRIR
     ELRETFDGLE DPNEGVPSPD EEF
//
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