ID Q3J8J4_NITOC Unreviewed; 501 AA.
AC Q3J8J4;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Exopolyphosphatase {ECO:0000256|ARBA:ARBA00020416};
DE EC=3.6.1.11 {ECO:0000256|ARBA:ARBA00012451};
GN OrderedLocusNames=Noc_2394 {ECO:0000313|EMBL:ABA58852.1};
OS Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB
OS 11848 / C-107).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Nitrosococcus.
OX NCBI_TaxID=323261 {ECO:0000313|EMBL:ABA58852.1, ECO:0000313|Proteomes:UP000006838};
RN [1] {ECO:0000313|Proteomes:UP000006838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107
RC {ECO:0000313|Proteomes:UP000006838};
RX PubMed=16957257; DOI=10.1128/AEM.00463-06;
RA Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J.,
RA Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T.,
RA Vergez L.M., Ward B.B.;
RT "Complete genome sequence of the marine, chemolithoautotrophic, ammonia-
RT oxidizing bacterium Nitrosococcus oceani ATCC 19707.";
RL Appl. Environ. Microbiol. 72:6299-6315(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate;
CC Xref=Rhea:RHEA:21528, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14279,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16838,
CC ChEBI:CHEBI:43474; EC=3.6.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000209};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GppA/Ppx family.
CC {ECO:0000256|ARBA:ARBA00007125}.
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DR EMBL; CP000127; ABA58852.1; -; Genomic_DNA.
DR RefSeq; WP_002811615.1; NC_007484.1.
DR AlphaFoldDB; Q3J8J4; -.
DR STRING; 323261.Noc_2394; -.
DR KEGG; noc:Noc_2394; -.
DR eggNOG; COG0248; Bacteria.
DR HOGENOM; CLU_025908_4_0_6; -.
DR InParanoid; Q3J8J4; -.
DR Proteomes; UP000006838; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004309; F:exopolyphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006793; P:phosphorus metabolic process; IEA:InterPro.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR022371; Exopolyphosphatase.
DR InterPro; IPR048950; Ppx_GppA_C.
DR InterPro; IPR003695; Ppx_GppA_N.
DR InterPro; IPR030673; PyroPPase_GppA_Ppx.
DR NCBIfam; TIGR03706; exo_poly_only; 1.
DR PANTHER; PTHR30005; EXOPOLYPHOSPHATASE; 1.
DR PANTHER; PTHR30005:SF14; EXOPOLYPHOSPHATASE; 1.
DR Pfam; PF02541; Ppx-GppA; 1.
DR Pfam; PF21447; Ppx-GppA_III; 1.
DR PIRSF; PIRSF001267; Pyrophosphatase_GppA_Ppx; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:ABA58852.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000006838}.
FT DOMAIN 24..307
FT /note="Ppx/GppA phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02541"
FT DOMAIN 315..487
FT /note="Ppx/GppA phosphatase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21447"
SQ SEQUENCE 501 AA; 55572 MW; AACFD99A2AB05A1A CRC64;
MLSQRHPDTL AAIDLGSNSF HMIIARVVRE GQLQVLDRLR EMVQLAAGLD EAGCLSETAQ
ERALNCLARF GQRLRHLPPW AIRAVGTNTL RQANNADEFL KRASAALGHP IEVIAGDEEA
RLIYLGVSHA LDFDNARRLV VDIGGGSTEF IIGEGAEEGR YRQSIEMGCV RYSRCFFPQG
ELNKAAMRQA EIAARTMLQD FEQSFRHLGW EEAIGASGTI RTVARVVAAQ GWCGSGTITA
TSLKALVNRM IEAGHIKRLK FEGLSAERGP VFPGGVAVLK GIFESLGIER MMVSDGALRE
GLLYDLIGRI CHEDVRDRTV ADLAQRYHVD QFHACRVKNT ALALLEAAAS LWELEEEHAL
SLAWGAILHE AGLALSHSQY HKHGAYLLAY GDLPGFSQQE QQVLAFLVRG HRRKLPIAKL
DLLPEDLRQP TLRLCLLLRL AVLLNRNRSP VVLPPLTFKA EKNTLKLRFP DGWLLQHPLT
EADLVQEATY IKAAGYRLKI K
//
