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Database: UniProt
Entry: Q3JAJ3_NITOC
LinkDB: Q3JAJ3_NITOC
Original site: Q3JAJ3_NITOC 
ID   Q3JAJ3_NITOC            Unreviewed;       615 AA.
AC   Q3JAJ3;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   12-SEP-2018, entry version 93.
DE   RecName: Full=Malto-oligosyltrehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
DE            Short=MTHase {ECO:0000256|PIRNR:PIRNR006337};
DE            EC=3.2.1.141 {ECO:0000256|PIRNR:PIRNR006337};
DE   AltName: Full=4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
DE   AltName: Full=Maltooligosyl trehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
GN   OrderedLocusNames=Noc_1681 {ECO:0000313|EMBL:ABA58153.1};
OS   Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 /
OS   C-107).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Chromatiaceae; Nitrosococcus.
OX   NCBI_TaxID=323261 {ECO:0000313|EMBL:ABA58153.1, ECO:0000313|Proteomes:UP000006838};
RN   [1] {ECO:0000313|Proteomes:UP000006838}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107
RC   {ECO:0000313|Proteomes:UP000006838};
RX   PubMed=16957257; DOI=10.1128/AEM.00463-06;
RA   Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J.,
RA   Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M.,
RA   Poret-Peterson A.T., Vergez L.M., Ward B.B.;
RT   "Complete genome sequence of the marine, chemolithoautotrophic,
RT   ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707.";
RL   Appl. Environ. Microbiol. 72:6299-6315(2006).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of (1->4)-alpha-D-glucosidic
CC       linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to
CC       yield trehalose and (1->4)-alpha-D-glucan.
CC       {ECO:0000256|PIRNR:PIRNR006337}.
CC   -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC       {ECO:0000256|PIRNR:PIRNR006337}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|PIRNR:PIRNR006337, ECO:0000256|SAAS:SAAS00964676}.
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DR   EMBL; CP000127; ABA58153.1; -; Genomic_DNA.
DR   RefSeq; WP_002809072.1; NC_007484.1.
DR   ProteinModelPortal; Q3JAJ3; -.
DR   STRING; 323261.Noc_1681; -.
DR   CAZy; CBM48; Carbohydrate-Binding Module Family 48.
DR   CAZy; GH13; Glycoside Hydrolase Family 13.
DR   EnsemblBacteria; ABA58153; ABA58153; Noc_1681.
DR   KEGG; noc:Noc_1681; -.
DR   eggNOG; ENOG4105C9C; Bacteria.
DR   eggNOG; COG0296; LUCA.
DR   HOGENOM; HOG000155668; -.
DR   KO; K01236; -.
DR   OMA; FTPMLFM; -.
DR   OrthoDB; POG091H0CAL; -.
DR   BioCyc; NOCE323261:GCI3-1622-MONOMER; -.
DR   UniPathway; UPA00299; -.
DR   Proteomes; UP000006838; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0033942; F:4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR022567; DUF3459.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR004193; Glyco_hydro_13_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR012768; Trehalose_TreZ.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   Pfam; PF02922; CBM_48; 1.
DR   Pfam; PF11941; DUF3459; 1.
DR   PIRSF; PIRSF006337; Trehalose_TreZ; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   TIGRFAMs; TIGR02402; trehalose_TreZ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006838};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR006337,
KW   ECO:0000313|EMBL:ABA58153.1};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006337,
KW   ECO:0000313|EMBL:ABA58153.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006838}.
FT   DOMAIN      120    472       Aamy. {ECO:0000259|SMART:SM00642}.
FT   ACT_SITE    267    267       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006337-1}.
FT   ACT_SITE    303    303       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006337-1}.
FT   SITE        401    401       Transition state stabilizer.
FT                                {ECO:0000256|PIRSR:PIRSR006337-3}.
SQ   SEQUENCE   615 AA;  70225 MW;  4319F1A39B31FD49 CRC64;
     MQHCHGMPFG AEVTEKGTVR FRLWAPAAKQ VELCLEDTLE VVPLAMTPKE EGWFELETKE
     AGPGSLYCYQ INGGMRVPDP ASRFQPQDIH GPSEVVDPAT FKWQEEGWNG RPWEEAVIYE
     IHVGTFTPEG TFRGLESHLE HLAKLGVTAL ELMPVADFPG RWNWGYDGVS LFAPDSRYGR
     PHDLKSLVQA AHACGLMIFL DVVYNHFGPE GNYLHQYAPD FFTERHQTPW GAAINFDGKN
     AHWVRQFFIH NALFWLEEYQ FDGLRLDAVH AIQDDSKFHI LEELAETIFC HLDSRRRIHL
     VLENDNNIAR YLTRKPNGQP RWYTAQWNDD IHHALHVLTT QETTGYYLDY ADQPIAHLGR
     CLSEGFGYQG QHSPYREGKP RGEPSKILPP SAFVTFFQNH DQVGNRAFGE RITALITPEE
     VKALTALLLL SPFPPLLFMG QEWGSTQPFP FFCDFSEDLA ASVREGRRRE FAHFPEFNNP
     AAQERIPDPT AQATFDNAVL NWTHATNGKG KEWFELHQNL LKLRRQWIIP RLAAMRKNNG
     CYIPLGKQAL QVRWQLGDGA QLTILANLGK ISIFLSTLPS GEVLFTTFSD LNRILIHKNL
     PPKTVIWFLK ENSSD
//
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