ID Q3JEH2_NITOC Unreviewed; 401 AA.
AC Q3JEH2;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Malate dehydrogenase (Oxaloacetate decarboxylating) (NADP+) {ECO:0000313|EMBL:ABA56774.1};
DE EC=1.1.1.40 {ECO:0000313|EMBL:ABA56774.1};
GN OrderedLocusNames=Noc_0244 {ECO:0000313|EMBL:ABA56774.1};
OS Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB
OS 11848 / C-107).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Nitrosococcus.
OX NCBI_TaxID=323261 {ECO:0000313|EMBL:ABA56774.1, ECO:0000313|Proteomes:UP000006838};
RN [1] {ECO:0000313|Proteomes:UP000006838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107
RC {ECO:0000313|Proteomes:UP000006838};
RX PubMed=16957257; DOI=10.1128/AEM.00463-06;
RA Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J.,
RA Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T.,
RA Vergez L.M., Ward B.B.;
RT "Complete genome sequence of the marine, chemolithoautotrophic, ammonia-
RT oxidizing bacterium Nitrosococcus oceani ATCC 19707.";
RL Appl. Environ. Microbiol. 72:6299-6315(2006).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; CP000127; ABA56774.1; -; Genomic_DNA.
DR RefSeq; WP_011330274.1; NC_007484.1.
DR AlphaFoldDB; Q3JEH2; -.
DR STRING; 323261.Noc_0244; -.
DR KEGG; noc:Noc_0244; -.
DR eggNOG; COG0281; Bacteria.
DR HOGENOM; CLU_034446_2_1_6; -.
DR InParanoid; Q3JEH2; -.
DR Proteomes; UP000006838; Chromosome.
DR GO; GO:0004473; F:malate dehydrogenase (decarboxylating) (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABA56774.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006838}.
FT DOMAIN 13..146
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 158..394
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 401 AA; 42725 MW; 0F185F1C9115FB45 CRC64;
MATALGYHAE PRPGKLEISI TKPCATQQQL SLAYSPGVSV PVGAIVADPE AVYRYTAKGN
LVAVITDGSA VLGLGNTGPL ASKPVMEGKA VLFKSFAGLD AIDIEVEAES PEAFVDTVAR
ISPTFGGINL EDIAAPHCFM IEQALIERLD IPVLHDDQHG TAITIAAALQ NALELQGKSL
PEARIVCVGA GAAGIATLRL LVALGLDQEN ILLVDRQGVI REESQAPHSY CRPFISSSPK
RTLEEAIEGA DVFIGVAAPN LLTMEMLKSM ASRPIVFALS NPDPEIDPGL AHAARDDLIL
ATGRTDYPNQ VNNVLVFPFL FRAALNVRAR CINDAMKLAA VRALVELTKE PVPKQVLEAY
GEQQLAFGAN YILPKPLDPR LREFVTMAIT QAAIESGIAR I
//
