ID Q3KCN2_PSEPF Unreviewed; 596 AA.
AC Q3KCN2;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Pyruvate dehydrogenase, cytochrome {ECO:0000313|EMBL:ABA74473.1};
GN OrderedLocusNames=Pfl01_2732 {ECO:0000313|EMBL:ABA74473.1};
OS Pseudomonas fluorescens (strain Pf0-1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=205922 {ECO:0000313|EMBL:ABA74473.1, ECO:0000313|Proteomes:UP000002704};
RN [1] {ECO:0000313|EMBL:ABA74473.1, ECO:0000313|Proteomes:UP000002704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pf0-1 {ECO:0000313|EMBL:ABA74473.1,
RC ECO:0000313|Proteomes:UP000002704};
RX PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT "Genomic and genetic analyses of diversity and plant interactions of
RT Pseudomonas fluorescens.";
RL Genome Biol. 10:R51.1-R51.16(2009).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CP000094; ABA74473.1; -; Genomic_DNA.
DR RefSeq; WP_011334145.1; NC_007492.2.
DR AlphaFoldDB; Q3KCN2; -.
DR KEGG; pfo:Pfl01_2732; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_0_6; -.
DR Proteomes; UP000002704; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Pyruvate {ECO:0000313|EMBL:ABA74473.1};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 4..121
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 198..328
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 388..543
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 596 AA; 64517 MW; AFB5351D86C62CBE CRC64;
MTVTVGDFLV ERLSQWGVTR IFGYPGDGIN GVFGTLSRAG GKIEFVQARH EEMAAFMASA
HAKFTGELGV CIATSGPGAS HLITGLYDAR LDHMPVLAIV GQQARTALGS HYQQELDLVS
MFKDVAGAFV QQASAPSQVR HLLDRAVRTA IGERRVTALI LPNDLQDLEY KAPARAHGTA
HSGVGYSKPK VLPYDADLQR AADVLNAGEK VAILVGAGAL HASEQVFAIA EKLGAGVAKA
LLGKAVLPDE LPWVTGCIGL LGTEPSYKLM TECDTLLMIG SGFPYAEFLP KEGQARGVQI
DLQPDMLSLR YPMEVNLAGD AAETLAALAP LLEHKPLRKW RKKIEGWRAS WDKTLEKRAM
AKADPVNPQR VVYELSPRLP EQAIITSDSG SCANWFARDL KIRKGMKCSL SGGLASMGAA
VPYAIAAKFA FPQRPVIALV GDGAMQMNNM AELITVAKYW RQWDSPKWIC AVFNNEDLNQ
VTWEQRVMEG DPKFGASQSI PDVPYHLFAI SIGLKGIFVD REEDVAAAWE QALASEVPVV
IEFKTDPNVP PLPPHIKLEQ AKKFASTLLK GDPDEAGVIV QTAKQVLGTV LPGKRK
//
