ID DCA12_BOVIN Reviewed; 453 AA.
AC Q3MHH0; A6QR04;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=DDB1- and CUL4-associated factor 12 {ECO:0000305};
DE AltName: Full=WD repeat-containing protein 40A;
GN Name=DCAF12; Synonyms=WDR40A;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver, and Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3
CC ubiquitin-protein ligase complex of the DesCEND (destruction via C-end
CC degrons) pathway, which recognizes a C-degron located at the extreme C
CC terminus of target proteins, leading to their ubiquitination and
CC degradation. The C-degron recognized by the DesCEND pathway is usually
CC a motif of less than ten residues and can be present in full-length
CC proteins, truncated proteins or proteolytically cleaved forms (By
CC similarity). The DCX(DCAF12) complex specifically recognizes proteins
CC with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6
CC and CCT5, leading to their ubiquitination and degradation.
CC Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for
CC starvation-induced autophagy (By similarity). Also directly recognizes
CC the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative
CC degron in proteins such as MOV10, leading to their ubiquitination and
CC degradation. Controls the protein level of MOV10 during spermatogenesis
CC and in T cells, especially after their activation (By similarity).
CC {ECO:0000250|UniProtKB:Q5T6F0, ECO:0000250|UniProtKB:Q8BGZ3}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q5T6F0}.
CC -!- SUBUNIT: Component of the DCX(DCAF12) E3 ubiquitin ligase complex, at
CC least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF12 and RBX1.
CC {ECO:0000250|UniProtKB:Q5T6F0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5T6F0}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:Q5T6F0}. Nucleus {ECO:0000250|UniProtKB:Q5T6F0}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF12 family. {ECO:0000305}.
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DR EMBL; BC105241; AAI05242.1; -; mRNA.
DR EMBL; BC150062; AAI50063.1; -; mRNA.
DR RefSeq; NP_001161368.1; NM_001167896.1.
DR AlphaFoldDB; Q3MHH0; -.
DR SMR; Q3MHH0; -.
DR STRING; 9913.ENSBTAP00000028744; -.
DR PaxDb; 9913-ENSBTAP00000028744; -.
DR Ensembl; ENSBTAT00000028744.6; ENSBTAP00000028744.5; ENSBTAG00000021573.6.
DR GeneID; 525161; -.
DR KEGG; bta:525161; -.
DR CTD; 25853; -.
DR VEuPathDB; HostDB:ENSBTAG00000021573; -.
DR VGNC; VGNC:27901; DCAF12.
DR eggNOG; ENOG502QR7U; Eukaryota.
DR GeneTree; ENSGT00940000158028; -.
DR HOGENOM; CLU_020124_1_0_1; -.
DR InParanoid; Q3MHH0; -.
DR OMA; KMALWRI; -.
DR OrthoDB; 23695at2759; -.
DR TreeFam; TF323731; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000021573; Expressed in semen and 105 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0010506; P:regulation of autophagy; ISS:UniProtKB.
DR GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR GO; GO:0140627; P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19860:SF16; DDB1- AND CUL4-ASSOCIATED FACTOR 12; 1.
DR PANTHER; PTHR19860; DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..453
FT /note="DDB1- and CUL4-associated factor 12"
FT /id="PRO_0000306839"
FT REPEAT 138..178
FT /note="WD 1"
FT REPEAT 182..220
FT /note="WD 2"
FT REPEAT 250..289
FT /note="WD 3"
FT REPEAT 338..375
FT /note="WD 4"
FT REGION 1..38
FT /note="Required for nuclear location and interaction with
FT MOV10"
FT /evidence="ECO:0000250|UniProtKB:Q5T6F0"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 2
FT /note="A -> S (in Ref. 1; AAI05242)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 453 AA; 50636 MW; D353DA656E655DE4 CRC64;
MARKAVSRKR KAPALPGAGS DAQDPQFGWD HSLHKRKRLP PVKRSLVYYL KNREVRLQNE
TSYSRVLHGY AAQQLPSLLK EREFHLGTLN KVFASQWLNH RQVVCGTKCN TLFVVDVQTS
QITKIPILKD REPGCVTQQG CGIHAIELNP SRTLLATGGD NPNSLAIYRL PTLDPVCVGD
DGHKDWIFSI AWISDTMAVS GSRDGSMGLW EVTDDVLTKS DARHNVSRVP VYSHITHKAL
KDIPKEDTNP DNCKVRALAF NNKNKELGAV SLDGYFHLWK TENTLSKLLS TKLPYCRENV
CLAYGNEWSV YAVGSQAHVS FLDPRQPSYN VKSVCSRERG SGIRSVSFYE HIITVGTGQG
SLLFYDIRAQ RFLEEKLSAC YGSKPKLAGE NLKLTTGKGW LNHDETWRNY FSDIDFFPNA
VYTHCYDSSG TKLFVAGGPL PSGLHGNYAG LWS
//