ID Q3SE67_PARTE Unreviewed; 1331 AA.
AC Q3SE67;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN Name=RdRP1 {ECO:0000313|EMBL:CAI39057.1};
GN ORFNames=GSPATT00024768001 {ECO:0000313|EMBL:CAK92037.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAI39057.1};
RN [1] {ECO:0000313|EMBL:CAI39057.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D4-2 {ECO:0000313|EMBL:CAI39057.1};
RA Genoscope;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAI39057.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D4-2 {ECO:0000313|EMBL:CAI39057.1};
RA Le Mouel A., Meyer E.;
RT "RNA metabolism genes in Paramecium.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAK92037.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK92037.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
RN [4] {ECO:0000313|EMBL:CAK92037.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK92037.1};
RG Genoscope;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
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DR EMBL; CR932231; CAI39057.1; -; Genomic_DNA.
DR EMBL; CT868666; CAK92037.1; -; Genomic_DNA.
DR RefSeq; XP_001459434.1; XM_001459397.1.
DR STRING; 5888.Q3SE67; -.
DR EnsemblProtists; CAK92037; CAK92037; GSPATT00024768001.
DR GeneID; 5045219; -.
DR KEGG; ptm:GSPATT00024768001; -.
DR eggNOG; KOG0988; Eukaryota.
DR HOGENOM; CLU_259080_0_0_1; -.
DR InParanoid; Q3SE67; -.
DR OMA; ANGNICY; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0031380; C:nuclear RNA-directed RNA polymerase complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IBA:GO_Central.
DR GO; GO:0030422; P:siRNA processing; IBA:GO_Central.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT COILED 92..119
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1331 AA; 156012 MW; 24A04F2C141633FB CRC64;
MQQVLKVEFR TQLADEDYSS KIISDTNFNN FKNNKFLTNL LKDCIFDLEG ESFMQQQNDE
VDDDDEGVFS FQSMIEEQEE IQDITLIDAS KQRNKINKLQ EINQIVEKLE KALSKISKVD
IQIYDLKEAP LDAKLDSPLT VTLRMQKKYL CNFLKFHFSI IPNSQPVFMN FKNAQIIDDR
MQNQEYSIKI GKIPFTLNEL TFSYVTGEHL KDKLPDQPIN SPINLFLSPY FKFSDLQSQL
FKVKAYMMFH CEESKLARKV EFILNILDKF LLKIEVDLVN CQYCHAVTDS FGKKIHFKLL
CPPNYSISLS TKRKFELFNM KSDWIRVHNI FSNAYYNKYK NEIERLIIIN NTLITAQFTF
QQGSKEEMAY KMVIEKLSQY NLMYSDAIDL NLFELEQRKT QWDQLYALIE QSQLSFEQKY
NILCVVSQNR ITDLDLLKQL ILHITQFQRD NHEKILESTF QLFSRYSTDL NFSVRQSELN
KKNYLTFKRD LKRCLEDVII PIDQNEQKRV AMIKRVSLTP SGYIFNLKLP EETSEIIRQY
YNQLDNFIRL HFEDENLETI HGHHYITEYY FKSKLSNGLH LLGEQFRLLT WSASQLRGGS
CWIFNYNRAQ ISRQNFIDSI GNFNTLNMDQ VAKNAARLGQ NFSSSKSIDL RQIIVKTQVP
DKVGDNGKLY TDGIGKISRN LIEMIRVEMN NHTISAIQVR YHGAKGVLLL NDDLPDNTIE
LRKSMIKFNP TLMNDGNYKT MISLLDYNKF RGGYLNRQII ILLVTLGIQE EVFMQLQREY
LHKIANLSAV DSSIYNHFLV DYNGELQGLP SIIDNIRMMI NANLNENNNH YIKRVLDRLK
RRGLMQLRTK SNILMDQAAR VLGVVDDYDI LDQGEVVCIV KQSLDVNHKY ITGEIIVVRN
PCLHPGDIRK VRALSENEIL SRYNMKNPFA EYYNCIVFPC KGNSIPADCG GGDLDGDIYF
VSWDPKVIPK TTEYPMNYDE EKKPAVVVSK QIQAQGYISA EDFFQENKMI EFLLEYLNFD
VLGKIDNSHL AIADGSPDYA KDPKCIRLAE LHSAAVDYVK HGNKVEIPNN LVTKRWPDFM
EKDSMVYEST SILGKLYREV LQCINQEPQS VLDGYQQEGL PEIDTRFIYK FQQEDELAQV
GDQAKQYQDY YQNEYQQYLT DNICRNALKC LNHIFDNFDS LRKMFDLTNE YEIYTGYFTN
FTQGEGTRLK KKINVEHVQK RVILSLVQLK QEIYKTLSAN EEERLAEISI IHFLMMYSPK
SHQDQIAKYT SLKFYHQELE KTINKNEEIY KLFSRLKNKF PQWYRGCSWF FFTLEILSFA
QKTNDDSDEL I
//
