ID Q3SK56_THIDA Unreviewed; 737 AA.
AC Q3SK56;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Adenylyl cyclase class-3/4/guanylyl cyclase {ECO:0000313|EMBL:AAZ96936.1};
GN OrderedLocusNames=Tbd_0983 {ECO:0000313|EMBL:AAZ96936.1};
OS Thiobacillus denitrificans (strain ATCC 25259).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Thiobacillaceae; Thiobacillus.
OX NCBI_TaxID=292415 {ECO:0000313|EMBL:AAZ96936.1, ECO:0000313|Proteomes:UP000008291};
RN [1] {ECO:0000313|EMBL:AAZ96936.1, ECO:0000313|Proteomes:UP000008291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25259 {ECO:0000313|EMBL:AAZ96936.1,
RC ECO:0000313|Proteomes:UP000008291};
RX PubMed=16452431; DOI=10.1128/JB.188.4.1473-1488.2006;
RA Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT "The genome sequence of the obligately chemolithoautotrophic, facultatively
RT anaerobic bacterium Thiobacillus denitrificans.";
RL J. Bacteriol. 188:1473-1488(2006).
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DR EMBL; CP000116; AAZ96936.1; -; Genomic_DNA.
DR RefSeq; WP_011311495.1; NC_007404.1.
DR AlphaFoldDB; Q3SK56; -.
DR STRING; 292415.Tbd_0983; -.
DR KEGG; tbd:Tbd_0983; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG4252; Bacteria.
DR HOGENOM; CLU_000445_85_1_4; -.
DR OrthoDB; 9802500at2; -.
DR Proteomes; UP000008291; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR007890; CHASE2.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF05226; CHASE2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM01080; CHASE2; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008291};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 370..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 483..615
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 737 AA; 79098 MW; 0536FF13CF711716 CRC64;
MTRVSSRLLQ AGLSALFVLL IAAHVGGALH FDPIERVEAW LYDAWLKRTA PTGADDRIAI
LDIDEASLKS VGRWPWSRDT MTALVERLFD HYGVAAVGFD VVFAEADRSS GLDTLKALSQ
GELAGERAFA AALQKIAPRL DYDARFAEAL AERPVSLGYY FVPEGYRATR TGTLPPWSLP
PEVFGALKPG RPAAGYGANL APFQDAAQGA GFFNMLADDD GTARQMSLVL PYGEGYYLAL
SASTLRIAFG GDAASAGVEQ SELLGRNYLA PWLEVGGIRV PLGADGTVHV PYRAGSPFPY
ISAADVLAGK APVGQLENRI VLVGSTAPGL ADLRVTPFSS TFPGVEIHAH LIAGMLDGTT
RVTPPWARDA RLAAVLLLGA VLIVVLLRFG PALGLAATLA LLGLLLAAYG AAWARFQVVP
MAAPMLAVAG LYALNTAYGL FAATRSKRQI TRLFGQYVPP ELAAEMSRDP AHYTMEGQSR
DMSVLFSDIR GFTNFSEKLS PTELSEVLNA YLSTMTRIVQ QHQGTIDKYI GDAIMAFWNA
PVDLADHAAR AVRTALEMQA ALPQLNDEFA ARGWPAVKIG VGVNTGRMSV GNMGSEFRMA
YTVMGDAVNL GSRLEGITKQ YGVGILVTQS TVDADPVHAY MKVDEVRVKG KETPVAIYEP
LGAKDRLADD VRSAAAAFDA AFAAYQKQDW DAAETALRAL DAKSPRALYD VYLERIAQFR
AAPPPQGWDG VYVYTTK
//
