ID Q3SME9_THIDA Unreviewed; 1023 AA.
AC Q3SME9;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Heavy metal efflux pump CzcA {ECO:0000313|EMBL:AAZ96096.1};
GN OrderedLocusNames=Tbd_0143 {ECO:0000313|EMBL:AAZ96096.1};
OS Thiobacillus denitrificans (strain ATCC 25259).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Thiobacillaceae; Thiobacillus.
OX NCBI_TaxID=292415 {ECO:0000313|EMBL:AAZ96096.1, ECO:0000313|Proteomes:UP000008291};
RN [1] {ECO:0000313|EMBL:AAZ96096.1, ECO:0000313|Proteomes:UP000008291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25259 {ECO:0000313|EMBL:AAZ96096.1,
RC ECO:0000313|Proteomes:UP000008291};
RX PubMed=16452431; DOI=10.1128/JB.188.4.1473-1488.2006;
RA Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT "The genome sequence of the obligately chemolithoautotrophic, facultatively
RT anaerobic bacterium Thiobacillus denitrificans.";
RL J. Bacteriol. 188:1473-1488(2006).
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000116; AAZ96096.1; -; Genomic_DNA.
DR RefSeq; WP_011310656.1; NC_007404.1.
DR AlphaFoldDB; Q3SME9; -.
DR STRING; 292415.Tbd_0143; -.
DR KEGG; tbd:Tbd_0143; -.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_4; -.
DR OrthoDB; 9176633at2; -.
DR Proteomes; UP000008291; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF68; PROBALE CATION EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008291};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 887..905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 917..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 959..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1023 AA; 109205 MW; FB4BC13D7D055943 CRC64;
MLDTLTEFAL ARRWLILVLA LALAGFGVRA FQQLPIDAFP DVSTTQVKLI LKAPGMTPEE
VEARIAQPVE TELLGIPHQT VLRSLSKNAL VDITVDFEEG TDIYWARQQV SERFANAKSD
LPDNVSGGLA PISTPLSELF MFTVEGPLSL AEKRTLLDWT IRPQLRALPG VADVNALGGR
VATFAVSPDP VALAARGVTL GELRAALEAN TRKAGAGRVN EGEETWVVRV DAGVASLDSL
RRIGVKAVGP TVVTVGDVAS VEMGELTRYG AVTQNGRGEA VEGLVIGLKG VNAGLLIENV
KARLAEIEAT LPKGVSLSPF YDRAQLVDRA VGTVSTALLE AAVLVVVLLL LFLGNLRAAV
VVALILPLSV LATFVLMRQF GLSANLMSLG GLAIAIGLLV DAAVVVVENV VAHLAHDAET
TGGTRQQRVL WAVQEVSVPV ASGIAIIAIV FLPLLTLEGL EGKLFAPVAL TIVFALAASL
LLALTAIPVL ASVLLKRAAH EDPWLLRRAR ALYEPLLDRS LARPKRVYAA AALLMVAAVA
VYPTIGKTFM PVMDEGDILV QLEKLPSISL EAAVAQDLRV QQALLKNVPE IRRIVARAGA
DELGLDPMSL NDTDSFLVLK PVSEWRKRDK AWLTDEIRKV VDGFPGIAYN FTQPIDMRVS
EMLTGSRGDV AIKIFGPDLA TLNRLAAQIF QVVEKVPGAS DVYTPQNAGV QYLQAEIDRD
AAARFGLSAD EVGLLLRTQL EGEVIGTIQQ QGRRVPLQLR GPQALRESPD ALQAIRLTLA
DGREISLDQV VRLKRTTGPV AVKRENAARF TVVQSNVAGR DLVSFVGDAQ RAVAREVKLP
PGYHLAWGGQ FENQQRAAER LMIVVPVALL LIGFLLYVTF GNAAQALLVM MNVPLALIGG
IFALAASGEY LSVPASVGFI ALLGIAVLNG VVLVSHFNQL RAQGIKGDAV VREGALRRLR
PVLMTASIAA FGLVPLLFAT GPGSEIQRPL AIVVIGGLVS ATLLTLVMLP LLYRQFILKG
ARA
//
