GenomeNet

Database: UniProt
Entry: Q3SZ40
LinkDB: Q3SZ40
Original site: Q3SZ40 
ID   DDX56_BOVIN             Reviewed;         546 AA.
AC   Q3SZ40;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-OCT-2019, entry version 92.
DE   RecName: Full=Probable ATP-dependent RNA helicase DDX56;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein 56;
GN   Name=DDX56;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in later stages of the processing of the
CC       pre-ribosomal particles leading to mature 60S ribosomal subunits.
CC       Has intrinsic ATPase activity (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: May form homooligomeric complexes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX56/DBP9
CC       subfamily. {ECO:0000305}.
DR   EMBL; BC103169; AAI03170.1; -; mRNA.
DR   RefSeq; NP_001029501.1; NM_001034329.2.
DR   SMR; Q3SZ40; -.
DR   STRING; 9913.ENSBTAP00000014014; -.
DR   PaxDb; Q3SZ40; -.
DR   PRIDE; Q3SZ40; -.
DR   Ensembl; ENSBTAT00000014014; ENSBTAP00000014014; ENSBTAG00000010602.
DR   GeneID; 508728; -.
DR   KEGG; bta:508728; -.
DR   CTD; 54606; -.
DR   VGNC; VGNC:27978; DDX56.
DR   eggNOG; KOG0346; Eukaryota.
DR   eggNOG; ENOG410XR15; LUCA.
DR   GeneTree; ENSGT00550000074946; -.
DR   HOGENOM; HOG000253015; -.
DR   InParanoid; Q3SZ40; -.
DR   KO; K14810; -.
DR   OMA; RYRAQDC; -.
DR   OrthoDB; 973872at2759; -.
DR   TreeFam; TF300620; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000010602; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN         1    546       Probable ATP-dependent RNA helicase
FT                                DDX56.
FT                                /FTId=PRO_0000282326.
FT   DOMAIN       38    218       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      230    424       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      51     58       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF         7     35       Q motif.
FT   MOTIF       166    169       DEAD box.
FT   MOD_RES     126    126       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9NY93}.
FT   MOD_RES     141    141       Phosphothreonine.
FT                                {ECO:0000250|UniProtKB:Q9NY93}.
FT   MOD_RES     531    531       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9NY93}.
SQ   SEQUENCE   546 AA;  61254 MW;  0E3E4A6F09983404 CRC64;
     MEDPESLGFE HMGLDHRLLQ AVTDLGWSRP TLIQEKAIPL ALEGKDLLAR ARTGSGKTAA
     YAIPMLQLLL HRKATGPVVE QAVRALVLVP TKELARQAQS MIQQLAAYCA RDIRVANVSA
     AEDSASQRAV LMEKPDVVVG TPSRILNHLQ QDNLKLRDSM ELLVVDEADL LFSFGFEEEL
     KSLLCHLPRI YQAFLMSATF NEDVQALKEL VLHNPVTLKL QESQLPGPDQ LQQFQVVCET
     EEDKFLLLYA LLKLSLIRGK SLLFVNTLER SYRLRLFLEQ FSIPACVLNG ELPLRSRCHI
     ISQFNQGFYD CVIATDAEVL GPPVKGKHRG KGPKRDKASD PEAGVARGID FHHVCAVLNF
     DLPPTPEAYI HRAGRTARAN NPGIVLTFVL PTEQSQLGKI EELLSGDSGA PVLLPYQFHM
     EEIEGFRYRC RDAMRSVTKQ AIREARLKEI KEELLHSEKL KTYFEDNPRD LQLLRHDLPL
     HPAVVKPHLG NVPDYLVPPA LRGLVHPHKK RKKPLASKKA KKAKTQNPLR SFKHRGEKCR
     PTAAPS
//
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