GenomeNet

Database: UniProt
Entry: Q3TPE9
LinkDB: Q3TPE9
Original site: Q3TPE9 
ID   ANKY2_MOUSE             Reviewed;         440 AA.
AC   Q3TPE9; Q8BK14; Q8BYW5; Q8R3N4; Q921J1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   08-MAY-2019, entry version 99.
DE   RecName: Full=Ankyrin repeat and MYND domain-containing protein 2;
GN   Name=Ankmy2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   INTERACTION WITH GC1.
RX   PubMed=21124868; DOI=10.1371/journal.pgen.1001199;
RA   Jensen V.L., Bialas N.J., Bishop-Hurley S.L., Molday L.L., Kida K.,
RA   Nguyen P.A., Blacque O.E., Molday R.S., Leroux M.R., Riddle D.L.;
RT   "Localization of a guanylyl cyclase to chemosensory cilia requires the
RT   novel ciliary MYND domain protein DAF-25.";
RL   PLoS Genet. 6:E1001199-E1001199(2010).
CC   -!- FUNCTION: May be involved in the trafficking of signaling proteins
CC       to the cilia. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the retinal-specific guanylyl cyclase GC1.
CC       {ECO:0000269|PubMed:21124868}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3TPE9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3TPE9-2; Sequence=VSP_019937, VSP_019938;
CC         Note=No experimental confirmation available.;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC29839.1; Type=Frameshift; Positions=369; Evidence={ECO:0000305};
DR   EMBL; AK037644; BAC29839.1; ALT_FRAME; mRNA.
DR   EMBL; AK077556; BAC36860.1; -; mRNA.
DR   EMBL; AK164434; BAE37787.1; -; mRNA.
DR   EMBL; BC012275; AAH12275.1; -; mRNA.
DR   EMBL; BC024959; AAH24959.1; -; mRNA.
DR   CCDS; CCDS25885.1; -. [Q3TPE9-1]
DR   RefSeq; NP_666145.3; NM_146033.3. [Q3TPE9-1]
DR   SMR; Q3TPE9; -.
DR   BioGrid; 229918; 1.
DR   IntAct; Q3TPE9; 1.
DR   STRING; 10090.ENSMUSP00000039484; -.
DR   iPTMnet; Q3TPE9; -.
DR   PhosphoSitePlus; Q3TPE9; -.
DR   EPD; Q3TPE9; -.
DR   MaxQB; Q3TPE9; -.
DR   PaxDb; Q3TPE9; -.
DR   PeptideAtlas; Q3TPE9; -.
DR   PRIDE; Q3TPE9; -.
DR   Ensembl; ENSMUST00000041640; ENSMUSP00000039484; ENSMUSG00000036188. [Q3TPE9-1]
DR   GeneID; 217473; -.
DR   KEGG; mmu:217473; -.
DR   UCSC; uc007njs.2; mouse. [Q3TPE9-2]
DR   UCSC; uc007njt.2; mouse. [Q3TPE9-1]
DR   CTD; 57037; -.
DR   MGI; MGI:2144755; Ankmy2.
DR   eggNOG; KOG1710; Eukaryota.
DR   eggNOG; ENOG410XPNY; LUCA.
DR   GeneTree; ENSGT00390000016820; -.
DR   HOGENOM; HOG000252933; -.
DR   InParanoid; Q3TPE9; -.
DR   OMA; HWFMHKK; -.
DR   OrthoDB; 1413951at2759; -.
DR   PhylomeDB; Q3TPE9; -.
DR   TreeFam; TF351374; -.
DR   ChiTaRS; Ankmy2; mouse.
DR   PRO; PR:Q3TPE9; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   Bgee; ENSMUSG00000036188; Expressed in 268 organ(s), highest expression level in pituitary gland.
DR   Genevisible; Q3TPE9; MM.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR002893; Znf_MYND.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01753; zf-MYND; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
DR   PROSITE; PS50865; ZF_MYND_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; ANK repeat; Cell projection; Cilium;
KW   Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    440       Ankyrin repeat and MYND domain-containing
FT                                protein 2.
FT                                /FTId=PRO_0000247167.
FT   REPEAT       45     74       ANK 1.
FT   REPEAT       79    108       ANK 2.
FT   REPEAT      159    188       ANK 3.
FT   ZN_FING     320    357       MYND-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00134}.
FT   VAR_SEQ     295    300       GSDPTA -> VRLLFC (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_019937.
FT   VAR_SEQ     301    440       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_019938.
FT   CONFLICT    156    156       L -> Q (in Ref. 1; BAC36860).
FT                                {ECO:0000305}.
FT   CONFLICT    357    357       C -> G (in Ref. 2; AAH24959).
FT                                {ECO:0000305}.
SQ   SEQUENCE   440 AA;  48774 MW;  8E9B74469A54EB7A CRC64;
     MGHIKKGELT QEEKELLEVI GKGTVQEAGR LLSSKNVHVN CLDENGMTPL MHAAYKGKLE
     MCKLLLRHGA DASCHQHEHG YTALMFAALS GNKDITWVML EAGAETDVVN SVGRTAAQMA
     AFVGQHDCVA IINNFFPRER LDYYTKPQGL DKEPKLPPKL AGPLHKIITT TNLHPVKIVM
     LVSENPLLAD AAALGKCYRV MDLICEKCMK QRDMNEVLAM KMHYISCIFQ KCITFLKEGE
     NKLDTLIRSL LKGRASDGFP VYQEKIIRES IRKFPYCEAT LLQQLVRSIA PVEIGSDPTA
     FSVLTQAITG QVGFVDVEFC TTCGEKGASK RCSVCKMVIY CDQTCQKTHW FAHKKMCKSL
     KDVYEKQQIE AAKHKRQEEK NGNPNVSSNH VNEDQPEAEE GITQENSIPS DSVEGEKEAA
     NDTGLASAQD APTGPQLSEE
//
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