GenomeNet

Database: UniProt
Entry: Q3TYX3
LinkDB: Q3TYX3
Original site: Q3TYX3 
ID   SMYD5_MOUSE             Reviewed;         416 AA.
AC   Q3TYX3; Q3TRB2; Q91YL6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 2.
DT   13-FEB-2019, entry version 92.
DE   RecName: Full=SET and MYND domain-containing protein 5;
DE            EC=2.1.1.-;
DE   AltName: Full=Protein NN8-4AG;
DE   AltName: Full=Retinoic acid-induced protein 15;
GN   Name=Smyd5; Synonyms=Rai15;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Inner ear, and Spinal cord;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   INDUCTION.
RX   PubMed=8754834; DOI=10.1128/MCB.16.8.4337;
RA   Shago M., Giguere V.;
RT   "Isolation of a novel retinoic acid-responsive gene by selection of
RT   genomic fragments derived from CpG-island-enriched DNA.";
RL   Mol. Cell. Biol. 16:4337-4348(1996).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Liver, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- INDUCTION: Up-regulated by retinoic acid treatment in embryonic
CC       carcinoma cells. Present at low levels in untreated cells.
CC       {ECO:0000269|PubMed:8754834}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH16525.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AK158267; BAE34438.1; -; mRNA.
DR   EMBL; AK162926; BAE37118.1; -; mRNA.
DR   EMBL; BC016525; AAH16525.1; ALT_INIT; mRNA.
DR   CCDS; CCDS51827.1; -.
DR   RefSeq; NP_659167.2; NM_144918.2.
DR   UniGene; Mm.219946; -.
DR   ProteinModelPortal; Q3TYX3; -.
DR   IntAct; Q3TYX3; 1.
DR   MINT; Q3TYX3; -.
DR   STRING; 10090.ENSMUSP00000048537; -.
DR   iPTMnet; Q3TYX3; -.
DR   PhosphoSitePlus; Q3TYX3; -.
DR   EPD; Q3TYX3; -.
DR   MaxQB; Q3TYX3; -.
DR   PaxDb; Q3TYX3; -.
DR   PeptideAtlas; Q3TYX3; -.
DR   PRIDE; Q3TYX3; -.
DR   Ensembl; ENSMUST00000045693; ENSMUSP00000048537; ENSMUSG00000033706.
DR   GeneID; 232187; -.
DR   KEGG; mmu:232187; -.
DR   UCSC; uc009cpq.1; mouse.
DR   CTD; 10322; -.
DR   MGI; MGI:108048; Smyd5.
DR   eggNOG; KOG2084; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   GeneTree; ENSGT00510000047420; -.
DR   HOGENOM; HOG000007877; -.
DR   HOVERGEN; HBG060385; -.
DR   InParanoid; Q3TYX3; -.
DR   OMA; MYCSSEC; -.
DR   OrthoDB; 1001347at2759; -.
DR   PhylomeDB; Q3TYX3; -.
DR   TreeFam; TF106419; -.
DR   PRO; PR:Q3TYX3; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   Bgee; ENSMUSG00000033706; Expressed in 236 organ(s), highest expression level in ear.
DR   Genevisible; Q3TYX3; MM.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Metal-binding; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    416       SET and MYND domain-containing protein 5.
FT                                /FTId=PRO_0000227789.
FT   DOMAIN       21    351       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING      98    136       MYND-type.
FT   COMPBIAS    383    412       Asp/Glu-rich.
FT   CONFLICT    354    354       C -> R (in Ref. 1; BAE34438).
FT                                {ECO:0000305}.
SQ   SEQUENCE   416 AA;  47095 MW;  2B9C3DFBF3362AD6 CRC64;
     MAASMCDVFS FCVGVADRAR GSVEVRYVDS IKGKGLFATQ LIRKGETIFI ERPLVAAQFL
     WNALYQYRAC DHCLRALEKA EENAQRLTGK PSQILPHPEL CSVRKDLHQN CPHCQVMYCS
     AECRLAAAEQ YHQILCPGPS HDPRHPLNKL QEAWRSVHYP PETASIMLMA RMVATVKQAK
     DKDHWVRLFN HFCSRTANQE QAIVHKLLKG KFKDQLELLL GLFKEALYEE ALSLWFTPEG
     FRSLFALVGT NGQGIGTSSL SQWVHACDAL ELTPQDREQL DTFIDQLYKD IEAATGEFLN
     CEGSGLFVLQ SCCNHSCVPN AETSFPENNF VLHVTALEDI KPGEEICISY LDCCQRERSR
     HSRHKILREN YLFNCSCPKC LAEADDPNVT SEEEEEEDEE EGEPEDAELG DEMTDV
//
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